Recombinant Human E3 ubiquitin-protein ligase RNF123 (RNF123), partial

中文名稱：

人RNF123重組蛋白
貨號(hào)：

CSB-YP713616HU
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

人RNF123重組蛋白
貨號(hào)：

CSB-EP713616HU
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

人RNF123重組蛋白
貨號(hào)：

CSB-EP713616HU-B
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RNF123重組蛋白
貨號(hào)：

CSB-BP713616HU
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

人RNF123重組蛋白
貨號(hào)：

CSB-MP713616HU
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

RNF123
Uniprot No.：

Q5XPI4
別名：

DKFZp686C2222; E3 ubiquitin protein ligase RNF123; E3 ubiquitin-protein ligase RNF123; FLJ12565; FP1477; Kip1 ubiquitination promoting complex protein 1; Kip1 ubiquitination-promoting complex protein 1; KPC 1; KPC1; MGC163504; RING finger protein 123; RN123_HUMAN; RNF 123; Rnf123; Ubiquitin ligase
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS.
基因功能參考文獻(xiàn)：
1. Findings indicate epigenetic regulation of E3 ubiquitin ligase KPC1 associated with NF-kappa B (NF-kappaB) pathway activation, promoting metastatic melanoma progression. PMID: 28389511
2. p27 and its cognate ubiquitin ligases, Skp2/KPC/Pirh2, are specifically involved in determining the clinical profiles of lung carcinomas. PMID: 28601655
3. RNF123 functions as a novel inhibitor of innate antiviral signaling mediated by RIG-I and MDA5, a function that does not depend on its E3 ligase activity. PMID: 27312109
4. Suggest that RNF213 R4810K carriers have lower angiogenic capacities, indicating that they might be more susceptible to insults of cerebral hypoxia. PMID: 26126547
5. Study identified KPC1 as the Ub ligase (E3) that binds to the ankyrin repeats domain of p105, ubiquitinates it, and mediates its processing both under basal conditions and following signaling. Overexpression of KPC1 inhibits tumor growth likely mediated via excessive generation of p50. PMID: 25860612
6. up-regulation of RNF123 was restricted to the cingulate cortex of patients with psychotic manifestations of the depression, supporting the role of the ubiquitin system in psychosis. PMID: 23668904
7. The number of patients with moyamoya disease, which is estimated at approximately one per 300 carriers of RNF123 polymorphism p.R4810K, is considered to be 53,800 in East Asian populations. PMID: 22688066
8. Our data support a role for RNF123 ubiquitin ligase in the degradation of HP1alpha and HP1beta upon lamin A/C knock-down PMID: 23077635
9. This study deministrated that genome-wide significant quantitative trait locus was localized on chromsome 4p15 exhibiting pleiotropic effects on both the endophenotype (lymphocyte-derived expression levels of the RNF123 gene) and disease risk. PMID: 21982424
10. Dendritic cell apoptosis was at least regulated by miR-221 and miR-155 through targeting the 3'-UTRs of p27kip1 and Kip1 ubiquitination-promoting complex 1 (KPC1), respectively. PMID: 21355095
11. KPC thus probably controls degradation of p27(Kip1) in G1 phase after export of the latter from the nucleus PMID: 15531880
12. Free p27 is recognized by the amino-terminal region of KPC1, which also associates with KPC2, and p27 is then polyubiquitylated by the carboxy-terminal RING-finger domain of KPC1. PMID: 15746103
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亞細(xì)胞定位：

Cytoplasm.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 21148

OMIM: 614472

KEGG: hsa:63891

STRING: 9606.ENSP00000328287

UniGene: Hs.553723