Recombinant Human Dihydrofolate reductase, mitochondrial (DHFRL1)

中文名稱：

人DHFR2重組蛋白
貨號：

CSB-YP773052HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人DHFR2重組蛋白
貨號：

CSB-EP773052HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人DHFR2重組蛋白
貨號：

CSB-EP773052HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人DHFR2重組蛋白
貨號：

CSB-BP773052HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人DHFR2重組蛋白
貨號：

CSB-MP773052HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

DHFR2
Uniprot No.：

Q86XF0
別名：

DHFR2; DHFRL1; DHFRP4Dihydrofolate reductase 2; mitochondrial; Dihydrofolate reductase; mitochondrial; EC 1.5.1.3; Dihydrofolate reductase-like protein 1
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-187
氨基酸序列

MFLLLNCIVA VSQNMGIGKN GDLPRPPLRN EFRYFQRMTT TSSVEGKQNL VIMGRKTWFS IPEKNRPLKD RINLVLSREL KEPPQGAHFL ARSLDDALKL TERPELANKV DMIWIVGGSS VYKEAMNHLG HLKLFVTRIM QDFESDTFFS EIDLEKYKLL PEYPGVLSDV QEGKHIKYKF EVCEKDD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.
基因功能參考文獻：
1. We hope this work will be useful to understand the general characteristics of DHFRL1. PMID: 24122410
2. The DHFRP4, or dihydrofolate reductase-like 1 (DHFRL1), gene is expressed and shares some commonalities with DHFR. PMID: 21876184
3. The results of this study suggest that genetic variants of methionine metabolism are associated with meningioma formation PMID: 18447718
亞細胞定位：

Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.
蛋白家族：

Dihydrofolate reductase family
組織特異性：

Expressed in numerous cell lines.
數據庫鏈接：

HGNC: 27309

OMIM: 616588

KEGG: hsa:200895

STRING: 9606.ENSP00000319170

UniGene: Hs.718516