Recombinant Human Deoxyribonuclease-1-like 1 (DNASE1L1)

中文名稱：

人DNASE1L1重組蛋白
貨號：

CSB-YP007050HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人DNASE1L1重組蛋白
貨號：

CSB-EP007050HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人DNASE1L1重組蛋白
貨號：

CSB-EP007050HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人DNASE1L1重組蛋白
貨號：

CSB-BP007050HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人DNASE1L1重組蛋白
貨號：

CSB-MP007050HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

DNASE1L1
Uniprot No.：

P49184
別名：

Deoxyribonuclease I-like 1; Deoxyribonuclease-1-like 1; DNAS1L1; DNase I like 1; DNase I like muscle specific; DNase I lysosomal like; DNase I-like 1; DNase X; DNASE1L1; DNASEX; DNL1L; DNSL1_HUMAN; Muscle specific DNase I like; Muscle-specific DNase I-like; XIB
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

19-302
氨基酸序列

FR ICAFNAQRLT LAKVAREQVM DTLVRILARC DIMVLQEVVD SSGSAIPLLL RELNRFDGSG PYSTLSSPQL GRSTYMETYV YFYRSHKTQV LSSYVYNDED DVFAREPFVA QFSLPSNVLP SLVLVPLHTT PKAVEKELNA LYDVFLEVSQ HWQSKDVILL GDFNADCASL TKKRLDKLEL RTEPGFHWVI ADGEDTTVRA STHCTYDRVV LHGERCRSLL HTAAAFDFPT SFQLTEEEAL NISDHYPVEV ELKLSQAHSV QPLSLTVLLL LSLLSPQLCP AA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

基因功能參考文獻：
1. genotyping of all 21 nonsynonymous DNase 1L1 SNPs was performed in 16 populations representing 3 ethnic groups; 2 activity-abolishing and 4 activity-reducing SNPs were confirmed to be functional; may be plausible that a minor allele of 6 SNPs producing a loss-of-function or low-activity variant could serve as a risk factor for disease PMID: 24329527
2. Yeast two-hybrid screening revealed that DNase X, a glycosylphosphatidyl inositol-anchored mammalian cell-surface protein binds EtpE-C. PMID: 24098122
3. DNASEX and TKTL1 detection in patient blood is associated with poor disease-free survival rate in oral squamous cell carcinoma. PMID: 24304513
4. Several SNPs in the deoxyribonuclease I-like 1 (DNase 1L1) and DNase 1L2 were investigated. PMID: 20967767
5. Genotyping of all the non-synonymous SNPs of was performed in three ethnic groups including six different populations using the PCR-RFLP method newly developed. PMID: 20503202
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亞細胞定位：

Endoplasmic reticulum.
蛋白家族：

DNase I family
組織特異性：

Highest levels in skeletal and cardiac muscles. Detectable in all other tissues tested except brain.
數據庫鏈接：

HGNC: 2957

OMIM: 300081

KEGG: hsa:1774

STRING: 9606.ENSP00000014935

UniGene: Hs.401929