Recombinant Human Death-inducer obliterator 1 (DIDO1), partial

中文名稱：

人DIDO1重組蛋白
貨號：

CSB-YP887120HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人DIDO1重組蛋白
貨號：

CSB-EP887120HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人DIDO1重組蛋白
貨號：

CSB-EP887120HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人DIDO1重組蛋白
貨號：

CSB-BP887120HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人DIDO1重組蛋白
貨號：

CSB-MP887120HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

DIDO1
Uniprot No.：

Q9BTC0
別名：

DIDO1; C20orf158; DATF1; KIAA0333Death-inducer obliterator 1; DIO-1; hDido1; Death-associated transcription factor 1; DATF-1
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Putative transcription factor, weakly pro-apoptotic when overexpressed. Tumor suppressor. Required for early embryonic stem cell development.; Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.
基因功能參考文獻：
1. Results identified a novel pH-dependent mechanism by which epigenetic reader, the PHD fingers of DIDO, recognize the histone mark H3K4me3. The pH-sensing ability might be necessary for normal biological processes and those characterized by altered cellular pH. PMID: 28919441
2. evaluated the Death Inducer-Obliterator (DIDO) (variants DIDO 1, 2 and 3) levels in CML, PV, ET and PMF patients. Our data reported the DIDO 1, 2 and 3 differential expressions in Myeloproliferative Neoplasms. PMID: 27282563
3. Dido1 induces the expression of Integrin alphaV, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells. PMID: 22469980
4. Data show that CSE1L, DIDO1 and RBM39 mRNA expression levels correlated with chromosome 20q DNA copy number status. PMID: 22711543
5. Gambogic acid induces the apoptosis of Raji cells through DIO-1 upregulation, nuclear translocation, Bcl-xL downregulation and caspase 3 activation. PMID: 19236754
6. Data suggest that Dido might be one of the tumor suppressor genes at chromosome 20q and that the Dido-targeted mouse may be a suitable model for studying myeloproliferative diseases and myelodysplastic syndromes. PMID: 16127461
7. Dido3, the largest splice variant of the Dido gene, is a centrosome-associated protein whose disruption leads to supernumerary centrosomes, failure to maintain cellular mitotic arrest, and early degradation of the mitotic checkpoint protein BubR1. PMID: 17299043
8. Gambogic acid induces DIDO1-mediated apoptosis in Jurkat T cells. PMID: 18298900
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亞細胞定位：

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle.
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 2680

OMIM: 604140

KEGG: hsa:11083

STRING: 9606.ENSP00000266070

UniGene: Hs.517172