Recombinant Human DNA excision repair protein ERCC-6-like (ERCC6L), partial

中文名稱：

人ERCC6L重組蛋白
貨號：

CSB-YP650698HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人ERCC6L重組蛋白
貨號：

CSB-EP650698HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人ERCC6L重組蛋白
貨號：

CSB-EP650698HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人ERCC6L重組蛋白
貨號：

CSB-BP650698HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人ERCC6L重組蛋白
貨號：

CSB-MP650698HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ERCC6L
Uniprot No.：

Q2NKX8
別名：

ATP dependent helicase ERCC6 like; ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC 6 like; DNA excision repair protein ERCC-6-like; ERC6L_HUMAN; ERCC 6L; Ercc6l; Excision repair cross complementing rodent repair deficiency complementation group 6 like; Excision repair protein ERCC6 like; FLJ20105; MGC131695; PICH; Plk1 interacting checkpoint helicase; PLK1-interacting checkpoint helicase; SNF2/RAD54 family protein; Tumor antigen BJ HCC 15; Tumor antigen BJ-HCC-15
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
基因功能參考文獻：
1. These findings suggested that ERCC6L, which is highly expressed in breast cancer, acts as an oncogene, is involved in breast cancer development and may serve as a novel molecular target for the treatment of breast cancer. PMID: 30066865
2. ERCC6L may stimulates cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2, and it could be a potential biomarker for cancer prognosis and target for cancer treatment. PMID: 28178669
3. Data indicate BEND3 as a new interaction partner for PICH in mitosis, and have defined the residues within a TPR-BEN domain interface that mediate this interaction. PMID: 28977671
4. Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex has been reported. PMID: 27487930
5. the mitotic roles of PICH and explore further the role of PICH in the timely segregation of the ribosomal DNA locus, are reported. PMID: 27565185
6. a novel SUMO-dependent regulation of PICH's function on mitotic centromeres, is reported. PMID: 27230136
7. PICH and Topo II cooperate to prevent chromosome missegregation events in mitosis. PMID: 26643143
8. PICH is a SUMO-interacting protein and a mitotic SUMO substrate. PMID: 25564610
9. PICH recognizes and stabilizes DNA under tension during anaphase, thereby facilitating the resolution of entangled sister chromatids. PMID: 23973328
10. PICH protein was required for the correct recruitment to the centromere of active topoisomerase IIalpha, an enzyme specialized in the catenation/decatenation process. PMID: 22563370
11. PICH binds to BLM and enables BLM localization to anaphase centromeric threads. PICH and BLM unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes. PMID: 21743438
12. the PICH-Plk1 complex plays a critical role in maintaining prometaphase chromosome architecture PMID: 20130082
13. the spindle checkpoint failure formerly attributed to the depletion of PICH most likely reflects an off-target effect that causes the lowering of Mad2 transcript and protein. PMID: 19904549
14. These data identify PICH as a novel essential component of checkpoint signaling. PMID: 17218258
15. The sensitivity to depletion of topo IIalpha might be linked to structural alterations within the centromere domain, indicated by shortening of the distance across metaphase sister centromeres and persistence of PICH-coated connections. PMID: 17956945
16. PICH phosphorylation and its ATPase activity are required for mitotic chromosome compaction through the targeting of Plk1 to chromosome arms. PMID: 18418076
17. Functional characterization of the mouse Ercc6l ortholog. PMID: 15917148
顯示更多

收起更多
亞細胞定位：

Chromosome, centromere. Chromosome, centromere, kinetochore. Chromosome.
蛋白家族：

SNF2/RAD54 helicase family
數據庫鏈接：

HGNC: 20794

OMIM: 300687

KEGG: hsa:54821

STRING: 9606.ENSP00000334675

UniGene: Hs.47558