Recombinant Human Cytosolic carboxypeptidase-like protein 5 (AGBL5), partial

中文名稱：

Recombinant Human Cytosolic carboxypeptidase-like protein 5(AGBL5) ,partial
貨號：

CSB-YP839858HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Cytosolic carboxypeptidase-like protein 5(AGBL5) ,partial
貨號：

CSB-EP839858HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Cytosolic carboxypeptidase-like protein 5(AGBL5) ,partial
貨號：

CSB-EP839858HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Cytosolic carboxypeptidase-like protein 5(AGBL5) ,partial
貨號：

CSB-BP839858HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Cytosolic carboxypeptidase-like protein 5(AGBL5) ,partial
貨號：

CSB-MP839858HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

AGBL5
Uniprot No.：

Q8NDL9
別名：

AGBL5; ATP/GTP binding protein like 5; ATP/GTP-binding protein-like 5; CBPC5_HUMAN; CCP5; Cytosolic carboxypeptidase like protein 5; Cytosolic carboxypeptidase-like protein 5; FLJ21839; Hypothetical protein FLJ21839
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.
基因功能參考文獻：
1. Homology models indicated destabilization of AGBL5 due to the p.Arg281Cys change. PMID: 27764769
2. The identification of AGBL5 and TTLL5, a previously described RP-associated gene encoding the tubulin tyrosine ligase-like family, member 5 protein, highlights the importance of poly- and deglutamylation in retinal homeostasis. PMID: 27842159
3. Due to the characteristic Retinitis Pigmentosa phenotype in patients carrying the AGBL5 missense mutation we suggest this gene as a candidate for a new form of autosomal recessively inherited RP PMID: 26720455
相關疾病：

Retinitis pigmentosa 75 (RP75)
亞細胞定位：

Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
蛋白家族：

Peptidase M14 family
組織特異性：

Expressed in brain.
數據庫鏈接：

HGNC: 26147

OMIM: 615900

KEGG: hsa:60509

STRING: 9606.ENSP00000353249

UniGene: Hs.138207