Recombinant Human Cortistatin (CORT)

中文名稱：

Recombinant Human Cortistatin(CORT)
貨號：

CSB-YP005821HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Cortistatin(CORT)
貨號：

CSB-EP005821HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Cortistatin(CORT)
貨號：

CSB-EP005821HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Cortistatin(CORT)
貨號：

CSB-BP005821HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Cortistatin(CORT)
貨號：

CSB-MP005821HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CORT
Uniprot No.：

O00230
別名：

CORT; UNQ307/PRO350Cortistatin [Cleaved into: Cortistatin-29; Cortistatin-17]
種屬：

Homo sapiens (Human)
蛋白長度：

Cytoplasmic domain
表達區域：

77-105
氨基酸序列

QEGA PPQQSARRDR MPCRNFFWKT FSSCK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
基因功能參考文獻：
1. Patients with newly diagnosed type 2 diabetes mellitus had lower plasma levels of vortistatin (CST) than healthy controls, and plasma CST was associated with glucose metabolism and insulin resistance. PMID: 28526556
2. There is a relationship between plamsa CST and BCKDK in sepsis patients. PMID: 27773658
3. Cortistatin emerges as a natural endogenous regulator of smooth muscle cells under pathological conditions and an attractive candidate for the pharmacological management of vascular diseases that course with neointimal lesion formation. PMID: 23595952
4. Identifies post-translational cleavage products of the homologous rat protein. PMID: 10461921
5. The cortistatin expression in the temporal lobe of Alzheimer's disease patients is decressed. PMID: 20164562
6. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. PMID: 12161511
7. first extensive study demonstrating that lymphoid tissues and immune cells express different levels of CST mRNA and that its expression can be regulated; hypothesize a role as an endogenous ligand of at least the sst2 receptor in the immune system PMID: 12519865
8. study demonstrates for the first time a selective and inducible expression of the recently discovered cortistatin, as well as somatostatin receptor 2, in human monocyte-derived cells PMID: 12684217
9. cortistatin-14 shown to be a high affinity ligand for G protein coupled receptor MrgX2 which is expressed in dorsal root ganglion PMID: 12915402
10. Cortistatin plays a role in the auto/paracrine regulation of the endocrine pancreas PMID: 14669820
11. Intravitreous somatostatin-like immunoreactivity deficit occurs in ptients with proliferative diabetic retinopathy. PMID: 16043736
12. Human immune cells produce CST, whereas macrophage lineage and activated endothelium express sst2, and human lymphocytes express sst3. The human thymus expresses sst1, 2, 3, MrgX2 and almost all immune cells express GHS-R. [review] PMID: 18450367
13. A lower expression of CST exists in diabetic retinas and it is associated with retinal neurodegeneration. PMID: 18709137
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亞細胞定位：

Secreted.
蛋白家族：

Somatostatin family
組織特異性：

Expressed in a subset of GABAergic cells in the cortex and hippocampus.
數據庫鏈接：

HGNC: 2257

OMIM: 602784

KEGG: hsa:1325

STRING: 9606.ENSP00000366248

UniGene: Hs.412311