Recombinant Human Cornulin (CRNN)

中文名稱：

Recombinant Human Cornulin(CRNN)
貨號：

CSB-YP005988HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Cornulin(CRNN)
貨號：

CSB-EP005988HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Cornulin(CRNN)
貨號：

CSB-EP005988HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Cornulin(CRNN)
貨號：

CSB-BP005988HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Cornulin(CRNN)
貨號：

CSB-MP005988HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CRNN
Uniprot No.：

Q9UBG3
別名：

53 kDa putative calcium binding protein; 53 kDa putative calcium-binding protein; 53 kDa squamous epithelial induced stress protein; 53 kDa squamous epithelial-induced stress protein; 58 kDa heat shock protein; C1orf10; Chromosome 1 open reading frame 10; Cornulin; CRNN; CRNN_HUMAN; DRC1; PDRC1; SEP53; Squamous epithelial heat shock protein 53; Tumor related protein; Tumor-related protein
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-495
氨基酸序列

MPQLLQNING IIEAFRRYAR TEGNCTALTR GELKRLLEQE FADVIVKPHD PATVDEVLRL LDEDHTGTVE FKEFLVLVFK VAQACFKTLS ESAEGACGSQ ESGSLHSGAS QELGEGQRSG TEVGRAGKGQ HYEGSSHRQS QQGSRGQNRP GVQTQGQATG SAWVSSYDRQ AESQSQERIS PQIQLSGQTE QTQKAGEGKR NQTTEMRPER QPQTREQDRA HQTGETVTGS GTQTQAGATQ TVEQDSSHQT GRTSKQTQEA TNDQNRGTET HGQGRSQTSQ AVTGGHAQIQ AGTHTQTPTQ TVEQDSSHQT GSTSTQTQES TNGQNRGTEI HGQGRSQTSQ AVTGGHTQIQ AGSHTETVEQ DRSQTVSHGG AREQGQTQTQ PGSGQRWMQV SNPEAGETVP GGQAQTGAST ESGRQEWSST HPRRCVTEGQ GDRQPTVVGE EWVDDHSRET VILRLDQGNL HTSVSSAQGQ DAAQSEEKRG ITARELYSYL RSTKP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways.
基因功能參考文獻：
1. This study showed a significant correlation between LOH/MSI at 1q21.3 with clinical outcomes and that downregulation of CRNN gene could be considered as a prognostic marker of OSCC. PMID: 25846277
2. The single-nucleotide polymorphisms of CRNN (rs941934) and RPTN (rs3001978, rs28441202) may contribute to Atopic Dermatitis development, but further studies on a larger group of Atopic Dermatitis patients are needed to verify this assumption. PMID: 28219068
3. Loss of CRNN expression correlated with advanced tumor length, greater tumor invasion depth, lymph node metastasis, and poor survival in patients with esophageal squamous cell carcinoma. PMID: 24263008
4. Findings demonstrate that CRNN is a tumor suppressor gene that plays a critical tumor suppressive role in ESCC. PMID: 23894350
5. cornulin is an important molecule in normal esophageal pathology and is likely lost during the conversion of normal to neoplastic epithelium PMID: 22560086
6. SEP53 may be a component of the mucosal/epithelial innate immune response engaged in an ongoing interaction with a pathogen PMID: 17925851
7. Results describe the cloning of porcine SEP53, its homology to the human protein, and its expression in the esophagus and in gastric squamous epithelium. PMID: 18465210
8. CRNN mRNA expression is decreased in eczematous skin PMID: 19133922
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亞細胞定位：

Cytoplasm. Note=Does not colocalize with TGM1.
蛋白家族：

S100-fused protein family
組織特異性：

Expressed in the basal skin layer (at protein level). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular l
數據庫鏈接：

HGNC: 1230

OMIM: 611312

KEGG: hsa:49860

STRING: 9606.ENSP00000271835

UniGene: Hs.242057