Recombinant Human Coiled-coil and C2 domain-containing protein 1A (CC2D1A), partial

中文名稱：

Recombinant Human Coiled-coil and C2 domain-containing protein 1A(CC2D1A) ,partial
貨號：

CSB-YP754171HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Coiled-coil and C2 domain-containing protein 1A(CC2D1A) ,partial
貨號：

CSB-EP754171HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Coiled-coil and C2 domain-containing protein 1A(CC2D1A) ,partial
貨號：

CSB-EP754171HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Coiled-coil and C2 domain-containing protein 1A(CC2D1A) ,partial
貨號：

CSB-BP754171HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Coiled-coil and C2 domain-containing protein 1A(CC2D1A) ,partial
貨號：

CSB-MP754171HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CC2D1A
Uniprot No.：

Q6P1N0
別名：

CC2D1A; AKI1Coiled-coil and C2 domain-containing protein 1A; Akt kinase-interacting protein 1; Five prime repressor element under dual repression-binding protein 1; FRE under dual repression-binding protein 1; Freud-1; Putative NF-kappa-B-activating protein 023N
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.
基因功能參考文獻：
1. Both expressions of CC2D1A and HTR1A genes studied on autism spectrum disorder cases and controls were significantly different PMID: 26782176
2. CC2D1A binds to CHMP4B polymers formed on endosomes to regulate the endosomal sorting pathway.CC2D1A regulates degradation and signaling of EGFR and TLR4. PMID: 27769858
3. Aki1 was expressed in human diffuse malignant mesothelioma specimens. Expression correlated with phosphorylated CREB1. Aki1 regulates CREB by modulating protein kinase A activity. The Aki1-CREB axis plays an important role in DMM pathogenesis. PMID: 26294214
4. Null mutations in CC2D1A consistently cause a variable spectrum of presentations including ID, ASD, and seizures. CC2D1A regulates NF-kappaB signaling. PMID: 25066123
5. All of the pancreatic cancer cell lines expressed Aki1. Silencing of Aki1 in Panc1 cells reduced the phosphorylation of Akt and increased the phosphorylation of cleaved PARP. PMID: 25036909
6. Non-genomic downregulation of 5-HT1A receptor by 17betaestradiol does not involve NUDR and Freud-1 proteins. PMID: 22328058
7. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity PMID: 22833682
8. CHMP4B interacts directly with CC2D1A and CC2D1B with nanomolar affinity by forming a 1:1 complex. PMID: 22406677
9. CC2D1A interaction with CHMP4B/4A blocks HIV-1 budding. PMID: 22258254
10. Results suggest the involvement of CC2D1A and CC2D2A in mental retardation in the Han Chinese population, and some specific haplotypes may be susceptible or protective. PMID: 22023432
11. Reductions in Freud-1 expression in prefrontal cortex may be associated with early onset of major depressive disorder. PMID: 20392296
12. Data suggest that the anti-tumor activity of NF-kappaB inhibitors is associated with p53-mediated activation of autophagy. PMID: 21274377
13. central role for TAPE (CC2D1A/Freud-1/Aki-1)in linking TLR3 and TLR4 to innate immune defenses at an early step PMID: 21189260
14. CC2D1A activates NF-kappaB through the canonical IKK pathway PMID: 20529849
15. these results indicate that cyclin B1-Cdk1 is a kinase of Aki1 during mitosis and that its phosphorylation of Aki1 may regulate mitotic function. PMID: 20171170
16. Centrosome-associated Aki1 and cohesin play pivotal roles in preventing premature cleavage in centriole cohesion. PMID: 19948489
17. A protein truncating mutation was identified in the gene CC2D1A in nine consanguineous families with severe autosomal recessive mental retardation. PMID: 16033914
18. a deletion in the CC2D1A gene has been linked to nonsyndromic mental retardation. This deletion results in the truncation of the helix-loop-helix DNA binding and the C2 domains. PMID: 17394259
19. Freud-1 has a key role in regulating DRD2 expression PMID: 17535813
20. disruption of transcriptional regulation by mutation of Freud-1 may play a role in abnormal brain function leading to mental retardation PMID: 17714190
21. Results suggest that Freud-1/Aki1 is a novel receptor-selective scaffold protein for the PDK1/Akt pathway and present a new activation mechanism of Akt. PMID: 18662999
22. Aki1 (Akt kinase-interacting protein 1)/CC2D1A/Freud-1 localized in centrosomes in addition to cytosol and in nucleus. Aki1 interacts with cohesin to prevent premature separase-mediated centriole disengagement. PMID: 19948489
23. CC2D1A associated with epidermal growth factor receptor (EGFR) in response to EGF stimulation, and was required for Akt activation induced by EGF, but not by insulin-like growth factor 1 (IGF-1). PMID: 18662999
24. Paper describes a function of Cc2d1a/Cc2d1b and their Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking. PMID: 17084358
25. Review of Freud-1 as a repressor of serotonin 1A receptor gene. PMID: 15534042
26. Freud-1 mediates HDAC-independent repression of the 5-HT1A receptor promoter in neuronal 5-HT1A-positive cells. PMID: 14756806
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相關疾病：

Mental retardation, autosomal recessive 3 (MRT3)
亞細胞定位：

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
蛋白家族：

CC2D1 family
數據庫鏈接：

HGNC: 30237

OMIM: 608443

KEGG: hsa:54862

STRING: 9606.ENSP00000313601

UniGene: Hs.269592