Recombinant Human Chondroadherin-like protein (CHADL)

中文名稱：

Recombinant Human Chondroadherin-like protein(CHADL)
貨號：

CSB-YP764668HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Chondroadherin-like protein(CHADL)
貨號：

CSB-EP764668HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Chondroadherin-like protein(CHADL)
貨號：

CSB-EP764668HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Chondroadherin-like protein(CHADL)
貨號：

CSB-BP764668HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Chondroadherin-like protein(CHADL)
貨號：

CSB-MP764668HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CHADL
Uniprot No.：

Q6NUI6
別名：

CHADL; SLRR4BChondroadherin-like protein
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

31-762
氨基酸序列

QRCPQACICD NSRRHVACRY QNLTEVPDAI PELTQRLDLQ GNLLKVIPAA AFQGVPHLTH LDLRHCEVEL VAEGAFRGLG RLLLLNLASN HLRELPQEAL DGLGSLRRLE LEGNALEELR PGTFGALGAL ATLNLAHNAL VYLPAMAFQG LLRVRWLRLS HNALSVLAPE ALAGLPALRR LSLHHNELQA LPGPVLSQAR GLARLELGHN PLTYAGEEDG LALPGLRELL LDGGALQALG PRAFAHCPRL HTLDLRGNQL DTLPPLQGPG QLRRLRLQGN PLWCGCQARP LLEWLARARV RSDGACQGPR RLRGEALDAL RPWDLRCPGD AAQEEEELEE RAVAGPRAPP RGPPRGPGEE RAVAPCPRAC VCVPESRHSS CEGCGLQAVP RGFPSDTQLL DLRRNHFPSV PRAAFPGLGH LVSLHLQHCG IAELEAGALA GLGRLIYLYL SDNQLAGLSA AALEGAPRLG YLYLERNRFL QVPGAALRAL PSLFSLHLQD NAVDRLAPGD LGRTRALRWV YLSGNRITEV SLGALGPARE LEKLHLDRNQ LREVPTGALE GLPALLELQL SGNPLRALRD GAFQPVGRSL QHLFLNSSGL EQICPGAFSG LGPGLQSLHL QKNQLRALPA LPSLSQLELI DLSSNPFHCD CQLLPLHRWL TGLNLRVGAT CATPPNARGQ RVKAAAAVFE DCPGWAARKA KRTPASRPSA RRTPIKGRQC GADKVGKEKG RL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment.
基因功能參考文獻：
1. Data show that a rare missense variant in the COMP gene (cartilage oligomeric matrix protein) and a frameshift variant in the CHADL gene (chondroadherin-like protein) strongly associate with osteoarthritis total hip replacement. PMID: 28319091
2. CHADL appears to have a negative regulatory role, possibly ensuring the formation of a stable extracellular matrix. PMID: 25451920
亞細胞定位：

Secreted. Secreted, extracellular space, extracellular matrix.
蛋白家族：

Small leucine-rich proteoglycan (SLRP) family, SLRP class IV subfamily
數據庫鏈接：

HGNC: 25165

OMIM: 616236

KEGG: hsa:150356

STRING: 9606.ENSP00000216241

UniGene: Hs.344488