Recombinant Human Chitinase-3-like protein 2 (CHI3L2)

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中文名稱：

Recombinant Human Chitinase-3-like protein 2(CHI3L2)
貨號(hào)：

CSB-EP620893HU
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：

￥1344
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

CHI3L2
Uniprot No.：

Q15782
別名：

CH3L2_HUMAN; CHI3L2; Chitinase 3 like 2; Chitinase-3-like protein 2; Chondrocyte protein 39; OTTHUMP00000014028; YKL 39; YKL-39; YKL39
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Full Length of Mature Protein
來(lái)源：

E.coli
表達(dá)區(qū)域：

27-390
氨基酸序列

YKLV CYFTNWSQDR QEPGKFTPEN IDPFLCSHLI YSFASIENNK VIIKDKSEVM LYQTINSLKT KNPKLKILLS IGGYLFGSKG FHPMVDSSTS RLEFINSIIL FLRNHNFDGL DVSWIYPDQK ENTHFTVLIH ELAEAFQKDF TKSTKERLLL TAGVSAGRQM IDNSYQVEKL AKDLDFINLL SFDFHGSWEK PLITGHNSPL SKGWQDRGPS SYYNVEYAVG YWIHKGMPSE KVVMGIPTYG HSFTLASAET TVGAPASGPG AAGPITESSG FLAYYEICQF LKGAKITRLQ DQQVPYAVKG NQWVGYDDVK SMETKVQFLK NLNLGGAMIW SIDMDDFTGK SCNQGPYPLV QAVKRSLGSL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 6xHis-SUMO-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.
基因功能參考文獻(xiàn)：
1. This study shown that CHI3L2 is regulated differently in healthy and late onset Alzheimer"s disease brain depending on the sex. PMID: 27653898
2. Structural analysis demonstrates that YKL-39 interacts with chitooligosaccharides through hydrogen bonds and hydrophobic interactions. Thermodynamic analysis indicates that binding of chitooligosaccharide to YKL-39 is mainly driven by enthalpy. PMID: 25477513
3. These data suggest that hYKL-39 is a novel growth and differentiation factor involved in cartilage homeostasis. PMID: 23291184
4. YKL-39 possesses a chitinase-like fold, but lacks key active-site residues required for catalysis. PMID: 22742450
5. ERK1/2 phosphorylation by CHI3L2 inhibits cell mitogenesis and proliferation. PMID: 22211103
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亞細(xì)胞定位：

Secreted.
蛋白家族：

Glycosyl hydrolase 18 family
組織特異性：

Highest expression in chondrocytes, followed by synoviocytes, lung and heart. Not detected in spleen, pancreas, and liver. May also be expressed in developing brain and placenta.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 1933

OMIM: 601526

KEGG: hsa:1117

STRING: 9606.ENSP00000358763

UniGene: Hs.514840