Recombinant Human Cathelicidin antimicrobial peptide (CAMP)

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中文名稱：

Recombinant Human Cathelicidin antimicrobial peptide(CAMP)
貨號：

CSB-EP004476HUb3
說明書：

MSDS Datasheet
規格：

￥1344
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

CAMP
Uniprot No.：

P49913
別名：

18 kDa cationic antimicrobial protein; Antibacterial peptide LL-37; Antibacterial protein FALL-39; CAMP; CAMP_HUMAN; CAP 18; CAP-18; CAP18; Cathelicidin antimicrobial peptide; Cathelin-like protein; Cathelin-related antimicrobial peptide; CATHL3; Cationic antimicrobial protein; 18-KD; CLP; Cnlp; Cramp; CRAMP; mouse; homolog of; FALL 39 ; FALL-39 peptide antibiotic; FALL39 ; hCAP 18; hCAP-18; hCAP18; HSD26 ; LL37; MCLP; Peptide antibiotic; PR-39; porcine; homolog of
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

24.7kDa
表達區域：

132-170aa
氨基酸序列

FALLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
基因功能參考文獻：
1. The correlation between serum LL-37 and high-density lipoprotein cholesterol levels suggests that LL-37 may play a key role in regulation of cholesterol levels in hypercholesterolemia. PMID: 29644526
2. LL-37/CRAMP represents an important mediator of platelet activation and thrombo-inflammation. PMID: 29670076
3. Low vitamin D3 status and higher systemic levels of LL-37 may be a consequence of reduced TB control and enhanced pathological inflammation. PMID: 29867045
4. these data show that LL-37 affects surface and intracellular Toll-Like Receptor expression in tissue mast cells PMID: 29670923
5. This review describes novel advances involving the roles and mechanisms of human cathelicidin LL-37 in cancer. PMID: 29843147
6. this study shows that LL-37 serum level correlates with healing of venous leg ulcers PMID: 27663530
7. Elevated serum levels of LL-37 in bipolar patients may suggest the role of this peptide in the pathomechanism of BD. PMID: 29239826
8. LL-37 serum levels are not affected by body composition in elderly women with unipolar depression. PMID: 28959904
9. The findings support a role for STAT3 and HIF-1A in the regulation of LL-37 expression. PMID: 27633343
10. In silico docking study have confirmed the high binding affinities of multiple 9-mer peptides derived from LL-37 to the HLA-C*06:02 molecule proposed a mechanism of the interaction between this LL-37-HLA-C*06:02 complex and T cells via TCRs. PMID: 27189829
11. IL-33 down-regulates the induction of hCAP-18/LL-37 production in human gingival epithelial cells. PMID: 28637951
12. in teens with positive recto-vaginal group B streptococcus colonization, placental mRNA expression of cathelicidin is lower compared to those who tested negative for this infection PMID: 28622535
13. Serum levels of LL-37 were found to be higher in elderly patients with major depressive disorder compared to controls. PMID: 28550757
14. these results suggested that human CAMP/LL-37 might act as a tumor-suppressor in OSCC and DNA methylation might play roles during carcinogenesis via directly downregulating human CAMP promoter activity. PMID: 28427192
15. omoted epithelial and smooth-muscle-like differentiation of Adipose-derived stem cells through activating the Wnt/beta-catenin and NF-kappaB pathways, respectively PMID: 29223160
16. Patients with type 1 diabetes and presence of microangiopathy characterize higher level of serum cathelicidin. PMID: 28964758
17. The expression of LL-37 was up-regulated in the inflamed mucosa of IBD patients. LL-37 was induced by TLR-3 stimulation and exhibited an anti-microbial effect via interaction with lipopolysaccharide (LPS). PMID: 28872665
18. the mean level of LL-37 was statistically significantly higher in TB patients than that in patients with Gram-positive bacteria-induced pneumonia (p < 0.001), in patients with Gram-negative bacteria-induced pneumonia (p < 0.001), and in healthy controls (p < 0.001). PMID: 28956425
19. data suggest that cathelicidin LL-37 is an important element of host defense in the course of bacterial diseases within the respiratory tract, particularly when the infection is caused by an intracellular pathogen. PMID: 28218580
20. This review summarizes the current knowledge on molecular mechanisms underlying LL-37-induced receptor activation. PMID: 27609777
21. L-CATH-2, D-CATH-2 and LL-37 can modulate the immune response of primary chicken immune cells by increasing mannose receptor expression, antigen presentation, endocytosis and neutralizing LPS-induced cytokine production and as a result augment activation of the adaptive immune system. PMID: 28715682
22. study demonstrated a substantial loss of antimicrobial function when the peptide was exposed to low concentrations of nanomaterials, and further showed that the nanomaterial-peptide interaction resulted in a significant change in the structure of the peptide PMID: 28814602
23. cathelicidin selectively modulated synthesis of TLR4 and 9 in intestinal epithelium, but only when cells were exposed to virulence factors, mostly from apical surfaces. PMID: 28988039
24. Autologous endothelial progenitor cells transfected by lentiviral vectors expressing antibiotic peptide LL37, as well as urothelial and smooth muscle cells from New Zealand white male rabbits, were cultured and seeded onto preconfigured acellular collagen-based tubular matrices PMID: 28739721
25. this study shows that LL-37 may aid clearance of influenza A virus by promoting monocyte uptake of the virus, while reducing viral replication and virus-induced TNF-a responses in these cells PMID: 27856789
26. Male placental cotyledons showed reduced basal CYP27B1 and cathelicidin gene expression compared to females. PMID: 27210415
27. Study demonstrates high levels of serum hBD2 and LL-37 levels in paediatric post- infectious bronchiolitis obliterans patients. These antimicrobial peptides may have important roles in immune systems and the pathogenesis of these patients. PMID: 26073571
28. the expression of CAMP, vitamin D receptor (VDR), and the retinoid X receptor (RXR) isoforms in human skin and gingival tissue biopsies and investigated the signaling pathways involved in 1alpha,25-dihydroxyvitamin D3-induced upregulation of CAMP. PMID: 27357804
29. A positive correlation was found between vitamin D and urine cathelicidin levels in the vitamin D sufficient group, however, there was no correlation between vitamin D and urine cathelicidin levels in the vitamin D insufficient group. PMID: 27180947
30. LL37 induced YB1 expression, and increased tumor cell proliferation, migration and invasion of A375 and A875 malignant melanoma cell lines. PMID: 27922666
31. this study shows that serum cathelicidin levels of acute asthma group are higher than controlled asthma group, and can be used to predict viral-induced acute asthma PMID: 27955890
32. Our results suggest that calcitriol anti-cancer therapy is more likely to induce higher levels of CAMP in ERalpha- breast cancer cells, when compared to ERa + breast cancer cells. PMID: 27832772
33. These findings highlight the role of cathelicidin in the pathogenesis of allergic rhinitis. PMID: 26777417
34. expressions of LL-37 mRNA and protein in the lesions of cutaneous tuberculosis and tuberculids were similar to that of normal skin PMID: 26960373
35. this study shows that carbamylation has profound and diverse effects on the structure and biological properties of LL-37. In some cases, anti-inflammatory LL-37 was rapidly converted to pro-inflammatory LL-37 PMID: 26878866
36. In rhinovirus infected cystic fibrosis patients, LL37 was inversely correlated with viral load in bronchoalveolar lavage fluid. PMID: 26585423
37. we discuss 1,25D3-induced down-regulation of cytokine/chemokine production and stimulation of hCAP-18/LL-37 gene expression which represent two very important pathways for 1,25D3-evoked regulation of the innate immune response--{REVIEW} PMID: 26433491
38. this study provides evidence for the ability of LL37 to bind and internalize viral or endogenous DNA into non-immune cells. PMID: 26297208
39. The human cathelicidin LL-37--A pore-forming antibacterial peptide and host-cell modulator. PMID: 26556394
40. higher nasal levels are associated with protection against RSV infection, directly damages viral envelopes and disrupts viral particles PMID: 26873992
41. Data indicate that endoplasmic reticulum (ER) stress increase sphingosine-1-phosphate (S1P) production, in turn activating nuclear factor kappa B (NF-kappaB)-mediated cathelicidin antimicrobial peptide (CAMP) synthesis. PMID: 26903652
42. The authors show that the group A Streptococcus surface-associated M1 protein sequesters and neutralizes LL-37 antimicrobial activity through its N-terminal domain. PMID: 26468750
43. Cathelicidin appears to play different roles in the development of pulmonary sarcoidosis and tuberculosis. PMID: 26422567
44. Neonates with congenital pneumonia had significantly higher serum cathelicidin and lower serum 25(OH)D compared to controls. PMID: 25354286
45. Taken together, these observations suggest that activation of human mast cells by LL-37 could be modified by TLR2 ligands and the function of human mast cells could be switched from allergic reactions to innate immune response. PMID: 26778002
46. the use of hCAP-18 levels in blood plasma for differential diagnosis of neutropenic patients, was assessed. PMID: 26119962
47. LL37, HMGB1 and S100A9 are increased in serum during exacerbation in COPD patients PMID: 25931489
48. The aim of this project was to examine the functional impact of the human cathelicidin LL-37 and the mouse cathelicidin-related AMP (CRAMP) on the pathogenesis of lupus and arthritis. PMID: 25535966
49. LL-37 interacts with negatively charged membranes forming a stable aggregate, which may produce toroidal pores. There is also an aggregate with a higher oligomeric degree for interaction of LL-37 with neutral membranes. PMID: 26502164
50. Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37. PMID: 26416907
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亞細胞定位：

Secreted.
蛋白家族：

Cathelicidin family
組織特異性：

Expressed in bone marrow and testis and neutrophils.
數據庫鏈接：

HGNC: 1472

OMIM: 600474

KEGG: hsa:820

STRING: 9606.ENSP00000458149

UniGene: Hs.51120