Recombinant Human Calcium-activated potassium channel subunit beta-3 (KCNMB3), partial

中文名稱：

人KCNMB3重組蛋白
貨號：

CSB-YP878838HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人KCNMB3重組蛋白
貨號：

CSB-EP878838HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人KCNMB3重組蛋白
貨號：

CSB-EP878838HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人KCNMB3重組蛋白
貨號：

CSB-BP878838HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人KCNMB3重組蛋白
貨號：

CSB-MP878838HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

KCNMB3
Uniprot No.：

Q9NPA1
別名：

BK channel subunit beta 3; BK channel subunit beta-3; BKbeta 3; BKbeta3; Calcium activated potassium channel beta 3 subunit; Calcium activated potassium channel subfamily M subunit beta 3; Calcium activated potassium channel subunit beta 3; Calcium-activated potassium channel; Calcium-activated potassium channel subunit beta-3; Charybdotoxin receptor subunit beta 3; Charybdotoxin receptor subunit beta-3; EG435726; Gm5707; Hbeta 3; Hbeta3; K(VCA)beta 3; K(VCA)beta-3; KCMB3_HUMAN; KCNMB 2; KCNMB 3; KCNMB2; KCNMB3; KCNMBL; Large conductance voltage and Ca2+ activated potassium channel Maxi K beta 3 subunit; Maxi K channel subunit beta 3; Maxi K channel subunit beta-3; Potassium channel, calcium-activated large conductance, subfamily M, beta member 3; Potassium large conductance calcium activated channel beta 3 subunit; Potassium large conductance calcium activated channel subfamily M beta member 3; Slo beta 3; Slo-beta-3; subfamily M subunit beta-3
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
基因功能參考文獻：
1. Single-nucleotide polymorphism in KCNMB3 gene is associated with Insulin Resistance. PMID: 23826284
2. The frequency of the delA750 mutation was significantly increased in idiopathic generalized epilepsy (7.9%) compared to that in the controls (5.5%; P = 0.016, one-sided; OR = 1.52; 95%-CI: 1.05-2.21). PMID: 16958040
3. The KCNMB3 isoforms beta3a-d may have unique functions in primates. PMID: 18591419
亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

KCNMB (TC 8.A.14.1) family, KCNMB3 subfamily
組織特異性：

Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis.
數據庫鏈接：

HGNC: 6287

OMIM: 605222

KEGG: hsa:27094

STRING: 9606.ENSP00000319370

UniGene: Hs.591285