Recombinant Human Arachidonate 5-lipoxygenase-activating protein (ALOX5AP), partial
-
中文名稱：Recombinant Human Arachidonate 5-lipoxygenase-activating protein(ALOX5AP), partial
-
貨號：CSB-YP001625HU1
-
說明書：
-
規格：
-
來源：Yeast
-
其他：
-
中文名稱：Recombinant Human Arachidonate 5-lipoxygenase-activating protein(ALOX5AP), partial
-
貨號：CSB-EP001625HU1
-
說明書：
-
規格：
-
來源：E.coli
-
其他：
-
中文名稱：Recombinant Human Arachidonate 5-lipoxygenase-activating protein(ALOX5AP), partial
-
貨號：CSB-EP001625HU1-B
-
說明書：
-
規格：
-
來源：E.coli
-
共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
-
其他：
-
中文名稱：Recombinant Human Arachidonate 5-lipoxygenase-activating protein(ALOX5AP), partial
-
貨號：CSB-BP001625HU1
-
說明書：
-
規格：
-
來源：Baculovirus
-
其他：
產品詳情
-
純度：>85% (SDS-PAGE)
-
基因名：
-
Uniprot No.：
-
別名：ALOX5AP; FLAP; Arachidonate 5-lipoxygenase-activating protein; MK-886-binding protein
-
種屬：Homo sapiens (Human)
-
蛋白長度：partial, is Cytoplasmic domain, contains immunogen sequence
-
蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
-
儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
-
保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
-
注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
Datasheet ：Please contact us to get it.
產品評價
相關產品
靶點詳情
-
功能：Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
-
基因功能參考文獻：
- Phosphate steering is an unappreciated FLAP function that enforces 5'-flap specificity and catalysis, preventing genomic instability. PMID: 28653660
- This meta-analysis indicates that ALOX5AP rs17222919-1316T/G may be a protective factor against stroke. PMID: 30313062
- No significant association was found between ALOX5AP rs10507391 polymorphism and ischemic stroke risk in males. Moreover, ALOX5AP rs10507391 polymorphism was not associated with cardioembolic ischemic stroke risk. PMID: 29096760
- rs17222919 of ALOX5AP is a potential genetic protective factor against ischemic stroke in the Chinese population PMID: 27416969
- The results the study indicate that SNP genetic variants of ALOX5AP might play a role in the development of SSc-related pulmonary fibrosis and ventilatory dysfunction. PMID: 28160477
- Meta-analysis suggests that the A allele at the ALOX5AP SG13S114 polymorphism is a protective factor for the ischemic stroke in the European population PMID: 28101761
- Genetic polymorphisms of T-1131C APOA5 and ALOX5AP SG13S114 can be considered risk factors for the susceptibility to ischemic stroke in Morocco. PMID: 27350673
- Data indicate that a single amino acid mutation was sufficient to reverse the speciation observed in wild type 5-Lipoxygenase activating protein (FLAP). PMID: 27129215
- No association was found between single-nucleotide polymorphisms of ALOX5AP or PDE4D and the risk of overall ischemic stroke in a southeastern Chinese population. The ALOX5AP gene might be related to ischemic stroke incidence in females. PMID: 24485247
- Genetic interaction of CD80 and ALOX5AP was observed in systemic lupus erythematosus in Asian populations. PMID: 25862617
- findings show that several enzymes known to be involved in the biosynthesis of proinflammatory LTs, such as FLAP and cPLA2alpha, also contribute to LX and Rv formation PMID: 26289316
- The results of this study supported the association of the epistatic interactions of ALOX5AP, THBD, and KNG1 and present novel evidence for the main effect of KNG1 gene on IS susceptibility PMID: 26159646
- results of the meta-analysis indicate that ALOX5AP rs10507391/SG13S114 A>T polymorphism is not associated with the risk of cerebral infarction in the Chinese population. PMID: 25242267
- Genetic polymorphisms of ALOX5AP and CYP3A5 increase susceptibility to ischemic stroke and are associated with atherothrombotic events in stroke patients. PMID: 25534367
- Our study provides evidence that the promoter single nucleotide polymorphism (SNP) rs17222919 of the ALOX5AP is a potential genetic protective factor for IS in the Chinese Han population. PMID: 25815512
- Report no association between ALOX5AP SNPs and atherosclerotic plaque phenotypes. PMID: 25721704
- FLAP protein inhibition attenuates inflammation induced by lipopolysaccharides (LPS) or the lipid A fraction of LPS. PMID: 25025775
- Rs10507391, rs4769874 and its haplotypes in ALOX5AP are unrelated to ACS risk in the Chinese Han population of Changwu, but elevated serum LTB4 level is strongly associated withacute coronary syndrome risk PMID: 25210744
- A common genetic variant SG13S114/AA in ALOX5AP was associated with ischemic stroke in Chinese cohort. PMID: 24198186
- BRP-7 potently suppresses leukotriene biosynthesis by interacting with FLAP in human neutrophils/monocytes. PMID: 24641614
- ALOX5AP polymorphisms are associated with atherosclerotic cerebral infarction in a cigarette smoking Chinese population. PMID: 24411318
- This study showed that interactions between the ALOX5AP SG13S114 and CYP3A5 A6986G genes can engender a significantly higher risk of stroke than a single risk factor. PMID: 24368493
- There was no statistically significant association of ALOX5AP rs4073259 SNP with ischemic stroke in this northeastern Chinese Han population living in Heilongjiang province, China. PMID: 24635928
- This meta-analysis identifies three polymorphisms of ALOX5AP that are significantly associated with risk for the Chinese population to develop ischemic stroke. PMID: 24183033
- a protective role of the three ALOX5AP SNPs for stroke PMID: 25010723
- The cellular biosynthesis of 5-LO products from endogenously derived substrate requires not only functional 5-LO/FLAP co-localization but also additional prerequisites which are dispensable when exogenous AA is supplied PMID: 24905297
- The roles of CLP and FLAP in in cellular leukotriene biosynthesis, were studied. PMID: 25034252
- The two genetic polymorphisms of ALOX5AP, SG13S114 and SG13S32, are not associated with cerebral infarction. PMID: 23546934
- The results of our study failed to confirm whether the selected variants in ALOX5AP gene within the LT metabolism pathway contribute to platelet reactivity in a diabetic population treated with ASA. PMID: 23828562
- ALOX5AP SG13S114 polymorphism is associated with susceptibility to ischemic stroke in Chinese population. [review] PMID: 24148560
- the interaction between ALOX5AP-SG13S114AA and COX-2-765CC apparently increases susceptibility to cerebral infarction. PMID: 23765972
- Genetic variability in FLAP and ALOX15 may modify the protective effect of NSAID use against colorectal neoplasia. PMID: 23404351
- Data indicate that single-nucleotide polymorphisms (SNPs) in 5-lipoxygenase activating protein (ALOX5AP), phosphodiesterase 4D (PDE4D), and interleukin-1alpha (IL-1alpha) were associated with an increased risk of atherothrombotic stroke (ATS) in Chinese. PMID: 23076369
- The ALOX5AP SNP A allele in rs4073259 and genotype rs9579646 GG, rs9551963 AC, and haplotype rs9315050 & rs9551963 AAAC were associated with an increased risk of ischemic stroke. PMID: 22849376
- SNP haplotypes with susceptibility to coronary artery disease in a Chinese Han population PMID: 22726381
- study is the first to demonstrate the association between lung function and ALOX5AP polymorphisms in a healthy and general population PMID: 22537113
- Our data do not support the hypothesis that variants in ALOX5AP are associated with risk of MRI-defined brain infarcts. PMID: 22074807
- This study provides preliminary evidence suggesting that genetic polymorphisms of ALOX5AP are associated with atherothrombotic stroke. PMID: 22051033
- ALOX5AP SNPs are unlikely to play a dominant role in the pathogenesis of abdominal aortic aneurysms. PMID: 22129473
- The polymorphisms spanning ALOX5AP is not major determinants of baseline lung function in smokers. PMID: 22206291
- Genetic variants in the promoter region of the ALOX5AP gene might be a novel genetic risk factor for ischemic stroke in a north Chinese Han population. PMID: 21893978
- These results suggested that the genetic variants in ALOX5AP might modulate the risk of stroke in Eastern Chinese Han population. PMID: 21153769
- A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population PMID: 21816595
- No statistically significant associations were found between acute stroke and the ALOX5AP gene polymorphisms examined PMID: 21675249
- Polymorphisms of the 5-lipo-oxygenase-activating protein may be associated with chronic spontaneous urticaria. PMID: 21227888
- Data show that the HapB haplotype and rs1722842 polymorphism in ALOX5AP gene were associated with coronary heart disease, and the HapA haplotype was associated with risk of MI. PMID: 21199733
- The polymorphism of SG13S114A/T in ALOX5AP is not related with atherosclerotic cerebral infarction. PMID: 20014490
- LTA4H and ALOX5AP gene polymorphisms modify the augmentation of bronchodilator responsiveness by leukotriene modifiers in Puerto Ricans but not Mexicans with asthma. PMID: 20810156
- Our results support the role of LTA4H and ALOX5AP variants as risk factors for asthma in Latino populations. PMID: 20067482
- The ALOX5AP SG13S114 variant is an independent risk factor for ischemic stroke in the Iberian population and is associated with ALOX5AP expression levels PMID: 20357438
顯示更多
收起更多
-
相關疾?。?/div>Ischemic stroke (ISCHSTR)亞細胞定位：Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.蛋白家族：MAPEG family數據庫鏈接：
Most popular with customers
-
Recombinant Human Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
-AC1.jpg)
Recombinant Human T-cell surface protein tactile (CD96), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human C-C chemokine receptor type 8 (CCR8)-VLPs (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Mouse Cell adhesion molecule 1 (Cadm1), partial (Active)
Express system: Mammalian cell
Species: Mus musculus (Mouse)
-
Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Kidney-associated antigen 1(KAAG1) (Active)
Express system: Baculovirus
Species: Homo sapiens (Human)
-
Recombinant Human Mucin-13(MUC13),partial (Active)
Express system: yeast
Species: Homo sapiens (Human)
