Recombinant Human Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2), partial

中文名稱：

Recombinant Human Ankyrin repeat and LEM domain-containing protein 2(ANKLE2) ,partial
貨號：

CSB-YP771466HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Ankyrin repeat and LEM domain-containing protein 2(ANKLE2) ,partial
貨號：

CSB-EP771466HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Ankyrin repeat and LEM domain-containing protein 2(ANKLE2) ,partial
貨號：

CSB-EP771466HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Ankyrin repeat and LEM domain-containing protein 2(ANKLE2) ,partial
貨號：

CSB-BP771466HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Ankyrin repeat and LEM domain-containing protein 2(ANKLE2) ,partial
貨號：

CSB-MP771466HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ANKLE2
Uniprot No.：

Q86XL3
別名：

ANKL2_HUMAN; ANKLE 2 ; ANKLE2; ankyrin repeat and LEM domain containing 2; Ankyrin repeat and LEM domain-containing protein 2; FLJ 22280; FLJ 36132; FLJ22280; FLJ36132; KIAA 0692; KIAA0692; LEM domain containing 7; LEM domain-containing protein 4; LEMD 7 ; LEMD7
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development.
基因功能參考文獻：
1. Absence of ANKLE2 severely compromises the post mitotic re-association of the nuclear proteins BAF, LAP2alpha and LaminA to chromosomes. These defects give rise to a strong mechanical instability of the nuclear envelope in telophase and to a chromosomal instability leading to increased number of hyperploid cells. PMID: 29254732
2. By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans. PMID: 22770216
相關疾病：

Microcephaly 16, primary, autosomal recessive (MCPH16)
亞細胞定位：

Endoplasmic reticulum membrane; Single-pass type III membrane protein.
蛋白家族：

ANKLE2 family
數據庫鏈接：

HGNC: 29101

OMIM: 616062

KEGG: hsa:23141

STRING: 9606.ENSP00000350686

UniGene: Hs.654628