Recombinant Human Alpha-lactalbumin (LALBA)

中文名稱：

人LALBA重組蛋白
貨號：

CSB-YP012724HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人LALBA重組蛋白
貨號：

CSB-EP012724HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人LALBA重組蛋白
貨號：

CSB-EP012724HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人LALBA重組蛋白
貨號：

CSB-BP012724HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人LALBA重組蛋白
貨號：

CSB-MP012724HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

LALBA
Uniprot No.：

P00709
別名：

a-LACTA; alfaLA; Alpha-lactalbumin; Lactalbumin alpha; Lactose synthase B protein; LALBA; LALBA_HUMAN; Lysozyme-like protein 7; LYZL7; MGC138521; MGC138523
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

20-142
氨基酸序列

K QFTKCELSQL LKDIDGYGGI ALPELICTMF HTSGYDTQAI VENNESTEYG LFQISNKLWC KSSQVPQSRN ICDISCDKFL DDDITDDIMC AKKILDIKGI DYWLAHKALC TEKLEQWLCE KL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
基因功能參考文獻：
1. Studies indicate that alpha-lactalbumin has two domains, a large alpha-helical domain and a small beta-sheet domain connected by a calcium binding loop. PMID: 27238572
2. High molecular mass complexes are formed with alpha-lactalbumin and alphaB-crystallin, preventing the amorphous aggregation of alpha-lactalbumin. PMID: 23005341
3. analysis of macromolecular crowding on the structural stability of human alpha-lactalbumin PMID: 22735492
4. Data show that alpha-lactalbumin and CD14 form a complex in the gut which alters degradation of CD14, suggesting a mechanism by which this key LPS receptor may remain functional in the neonatal gut. PMID: 20717070
5. The complexes formed by partially folded alpha-lactalbumin with oleic acid display selective apoptotic activity against tumor cells. PMID: 19968717
6. comparison of the structural and stability properties of the isolated alpha-helical domain of lysozyme with that of alpha-lactalbumin PMID: 11718563
7. pH-dependent stability of the alpha-lactalbumin molten globule state. PMID: 12833543
8. Structural characterisation of the human alpha-lactalbumin molten globule at high temperature PMID: 12860137
9. a functional Ca(2+)-binding site is not required for conversion of alpha-lactalbumin to the active complex or to cause cell death PMID: 14627739
10. lipids are tissue-specific cofactors in alpha-lactalbumin protein folding PMID: 14627740
11. NMR study of the conformation of HAMLET, the folding variant of human alpha-lactalbumin, complexed to oleic acid. PMID: 15075403
12. The electrostatic nature of the alpha-lactalbumin (LA)-histone interaction justifies use of alpha-LA as a basis for design of antitumor agents, acting through disorganization of chromatin structure due to interaction between alpha-LA and histone. PMID: 15134431
13. a folding variant of alpha-lactalbumin has a role in lactating mammary gland apoptosis PMID: 15141307
14. the non-cooperative denaturation of the molten globule, alpha-lactalbumin secondary structure elements are stabilized by non-specific, non-native interactions PMID: 15558602
15. Fold and topology of alpha-lactalbumin may be formed from degenerate groups of side chains. PMID: 15956205
16. Local interactions as well as hydrophobic interactions formed in the molten globule state play an important role in organizing the structure in the transition state and in guiding the subsequent folding of alpha-lactalbumin. PMID: 16121399
17. Results describe the reaction mechanism and formation of CIDNP (chemically induced dynamic nuclear polarization) in the photoreactions of the dye 2,2'-dipyridyl with non-native states of bovine and human alpha-lactalbumins in aqueous solution. PMID: 16851644
18. alpha-lactalbumin molten globule has even more native-like character than suggested by studies conducted at higher temperature PMID: 18939797
19. recombinant human alpha-LA was purified from transgenic milk and displayed physicochemical properties similar to its natural counterpart with respect to molecular weight, structure, and regulatory activity for beta-1,4-galactosyltransferase PMID: 19038921
20. the structural preferences of the alpha-LA molten globule at pH 7 at the level of individual residues were investigated. PMID: 19766656
21. hydrogen exchange behavior of variants using mass spectrometry PMID: 11518539
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亞細胞定位：

Secreted.
蛋白家族：

Glycosyl hydrolase 22 family
組織特異性：

Mammary gland specific. Secreted in milk.
數據庫鏈接：

HGNC: 6480

OMIM: 149750

KEGG: hsa:3906

STRING: 9606.ENSP00000301046

UniGene: Hs.72938