Recombinant Human Alpha-actinin-3 (ACTN3)
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中文名稱:
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貨號:CSB-EP001243HU-B
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說明書:
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規格:
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來源:E.coli
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共軛:Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他:
產品詳情
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純度:>85% (SDS-PAGE)
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基因名:ACTN3
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Uniprot No.:
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別名:Alpha-actinin-3; Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein; ACTN3
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種屬:Homo sapiens (Human)
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蛋白標簽:Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式:Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet :Please contact us to get it.
相關產品
靶點詳情
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功能:F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
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基因功能參考文獻:
- ACTN3 gene dosage in muscle performance was investigated. PMID: 29706347
- ACTN3 is a genetic modifier of Duchenne muscular dystrophy. PMID: 28139640
- We constructed expression plasmids encoding mature mRNA that lacks introns or pre-mRNA, which carries introns for the ACTN3 577X gene (X and Xpre, respectively) and transfected the constructs into HEK293cells. Cells carrying the X gene, but not the Xpre gene, expressed exogenous truncated alpha-actinin-3 protein. PMID: 29857001
- The proportion of the ACTN3 RR genotype is significantly higher in boulderers than in professional sport climbers and may be related to the specific type of predisposition to this subdiscipline. PMID: 29401200
- Prevalence has been found of ACTN3 R577X and of ACE insertion / deletion gene polymorphisms in national and amateur Turkish athletes. PMID: 29729690
- RR and RX genotypes of the ACTN3 R577X polymorphism (corresponding to the presence of alpha-actinin-3 in type II muscle fibers) are associated with increased passive muscle stiffness of the human hamstring in vivo PMID: 29032593
- Concomitant presence of non-functional variant in ACTN3 gene decreased this beneficiary effect of ACE mutation on SBPR3. PMID: 29269700
- Study demonstrates it is unlikely that ACTN3 XX genotype provides an advantage in competitive endurance running performance. PMID: 29298672
- In humans, ACTN3 genotype alone does not contribute to alterations in body mass index or obesity. PMID: 28293018
- Our data indicated that ACTN3 RR genotype has higher maximal voluntary isometric contraction and lower flexibility than X-allele carriers at baseline, but the effect of ACTN3 R577X genotype on these two parameters is limited after isokinetic eccentric contractions. PMID: 29165731
- RR/RX ACTN3 and ACE DD genotypes may benefit athletes in activities that require strength and speed, while II ACE genotype may benefit athletes in endurance activities. PMID: 28177711
- findings suggest that the ACTN3 R577X genotype may influence decline in muscle and bone health phenotypes in older Korean adults. PMID: 28626757
- Tthe ACTN3 R577X polymorphism is a good predictor of both the lipid profile and the prognosis of nutritional intervention in reducing LDL in HIV+ patients. PMID: 27188902
- The children having both ACTN3 RR or RX genotype and ACE DD genotype showed high systolic blood pressure and low blood HDL cholesterol level, which may be considered a high-risk in metabolic syndrome. PMID: 26483160
- This study has thus revealed a novel nuclear complex of F-actin, DRR1 and COMMD1 that is involved in NF-kappaB degradation and cell cycle suppression in neuroblastoma cells. PMID: 28604741
- The RR genotype of ACTN3 R577X in the general Japanese population showed lower flexibility compared to the RX and XX genotypes. PMID: 28303562
- p16(INK4a) expression in MCF7 breast cancer cells leads to increased cell size, weakened intercellular adhesion and cortical re-distribution of cytoskeletal F-actin. PMID: 28395715
- our data showed a virtual absence of the variant (K) allele in MSTN rs1805086 in Japanese population, and no differences in allele/genotype frequencies in ACTN3 rs1815739 among centenarians and healthy controls of this country. PMID: 27861536
- Results indicate that the posthemorrhagic shock mesenteric lymph in vitro increases the cellular permeability of human umbilical vein endothelial cells through suppression of F-actin and VE-cadherin. PMID: 27338534
- These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion. PMID: 28161632
- The elite soccer players showed a tendency to a prevalence of ACTN3 RR and ACE DD genotypes both independently and in co-occurrence, in comparison with a general population. PMID: 28337894
- the ACTN3 R577X polymorphism influences the level of competition and lower-extremity power of elite Chinese sprint/power athletes PMID: 27442335
- It appears that the response of bone remodelling markers and undercarboxylated osteocalcin to exercise is not explained by the ACTN3 genotype PMID: 28254467
- We did not identify novel associations between physical activity and ACTN3. PMID: 28177749
- In comparison to RR homozygotes, X allele carriers for the R577X polymorphism of the ACTN3 gene presented higher values for typical markers of exercise-induced muscle damage during a competitive marathon. PMID: 28154975
- There was no statistically significant association between angiotensin-converting enzyme or alpha-actinin-3 polymorphisms and the presence of adolescent idiopathic scoliosis in females. PMID: 27819725
- Study suggests that ACTN3 R577X polymorphism is associated with non-acute ankle sprain in the Chinese Han population. PMID: 27966742
- X-allele triathletes in the ACTN3 R577X polymorphism presented greater signs of exercise-induced muscle damage during a half-ironman race than RR homozygotes. PMID: 27913923
- Studied the association between the ACTN3 R577X genotype and elite athlete status in a large Asian (Japanese) cohort of track and field athletes. 003). A significant linear correlation was found between the RR + RX genotype and athlete status. PMID: 26324221
- the influence of ACTN3 genotypes on the cost of locomotion was investigated. PMID: 26148057
- Most studies assessing healthy adults demonstrated that 577RX heterozygotes performed intermediately and/or similarly to the RR genotypes. Other studies showed no definitive genetic model with ACTN3 null allele heterozygosity on muscle performance. [review] PMID: 26429734
- Findings indicate that the IGF2 ApaI polymorphism, but not the ACTN3 R577X polymorphism, may be a candidate gene associated with some types of muscle strength and judo status. PMID: 26677828
- There may be a relationship between the ACTN3 genotype and HDL-C and adiponectin levels in rugby players. PMID: 26919654
- Actn3 controls sarcomeric composition and muscle function in a dose-dependent fashion. PMID: 26681802
- the ACE I/D and ACTN3 R577X (rs1815739) genetic variants in elite rugby athletes (rugby union and league) and genotype frequencies to controls and between playing positions, is reported. PMID: 26757799
- Our study provides no ervidence for an assocviation between alpha-actinin-3 R577x genotypes and differences in physical performance in adult, professional, U-20 and U-17 years Brazilian first-division soccer players PMID: 25650734
- ACTN3 and ACE genotypes influence sprint time in elite male athletes; No genotype differences were detected in sprint performance in both Caucasian and African ancestry sprinters PMID: 27075997
- These results suggest that the ACTN3 gene may play a significant role in determining muscle phenotypes. However, this gene is only one of many factors which could contribute to athletes' performance and muscle phenotypes. PMID: 25488167
- The present study provides novel findings associating the ACTN3 R577X polymorphism with physiological variables that are connected to endurance performance. PMID: 25939605
- Our results suggest that the ACTN3 R577X genotype is associated with lower-extremity muscle function in the Japanese population. PMID: 25761735
- New insights that have been made in understanding the molecular mechanisms that underlie the consequences of alpha-actinin-3 deficiency. PMID: 26802899
- F-actin and cell-matrix adhesions differently affect membrane dynamics and cell migration. PMID: 26248038
- The ACTN3 R577X is associated with acute ankle sprains in this study. PMID: 25687200
- This study aimed at determining the influence of the ACTN3 R577X polymorphism on muscle strength and muscle endurance in non-athletic young men PMID: 25761730
- Authors present a simple and cost-efficient method to genotype the ACTN3 r577x polymorphism by a single PCR. PMID: 25831089
- The ACTN3 R577X polymorphism is associated with cardiometabolic fitness in healthy young adults. PMID: 26107372
- This suggests that the ACTN3 gene has a greater impact on determining dynamic movements than influencing static muscle strength. PMID: 25734782
- We show that the ACTN3 R577X polymorphism is associated with human muscle volume and influences maximal isoinertial strength (1-RM) and maximum power (Wmax). PMID: 23384112
- These results suggest that factors associated with the ACTN3 XX genotype in canoe and kayak paddlers might provide some competitive advantage in performance at 1000 m, but it seems to limit at 200 m. PMID: 25268288
- ACTN3 R577X polymorphism modulates VO2 of a homogeneous untrained population, by differentiating VO2rep and VO2peak in XX genotype carriers, who may display higher aerobic capacity. PMID: 25569611
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蛋白家族:Alpha-actinin family
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組織特異性:Expressed only in a subset of type 2 skeletal muscle fibers.
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