Recombinant Human Adenylate cyclase type 8 (ADCY8), partial

中文名稱：

Recombinant Human Adenylate cyclase type 8(ADCY8) ,partial
貨號：

CSB-YP001344HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Adenylate cyclase type 8(ADCY8) ,partial
貨號：

CSB-EP001344HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Adenylate cyclase type 8(ADCY8) ,partial
貨號：

CSB-EP001344HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Adenylate cyclase type 8(ADCY8) ,partial
貨號：

CSB-BP001344HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Adenylate cyclase type 8(ADCY8) ,partial
貨號：

CSB-MP001344HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ADCY8
Uniprot No.：

P40145
別名：

ADCY8; Adenylate cyclase type 8; EC 4.6.1.1; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.
基因功能參考文獻：
1. Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women PMID: 26480920
2. Results show that promoter hypermethylation of ADCY8, CDH8, and ZNF582 are correlated with high-grade squamous intraepithelial lesion. PMID: 27651839
3. ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin secretion. PMID: 25403481
4. ADCY8 is integral for long-term potentiation and synaptic plasticity and is implicated in fear-related learning and memory. PMID: 24677629
5. Polymorphisms ADCY8 are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression. PMID: 23278386
6. The adenylate cyclase 8 plays a major role in cAMP production. PMID: 23200849
7. Orai1 and AC8 binding mediates dynamic interplay between Ca2+ and cAMP signaling PMID: 22494970
8. cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R. PMID: 21046358
9. Ca2+ entry increase was accompanied by red cell aggregation rise, while adenylyl cyclase-cAMP system stimulation led to red cell deformability increase and its aggregation lowered. PMID: 20675917
10. Data reveal that an association of the Ca(2+)-stimulable AC8 with AKAP79/150 that limits the sensitivity of AC8 to intracellular Ca(2+) events. PMID: 20410303
11. The data of this study suggested that Adcy8 might encode a translational behavioral endophenotype of bipolar disorder. PMID: 19691954
12. Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice expressing human adenylyl cyclase type 8. PMID: 12890691
13. A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A was shown PMID: 16258073
14. recruited CaM is used by the C terminus of AC8 to mediate Ca2+ stimulation PMID: 16613843
15. Redundant cyclase activity maintains the balance between presynaptically silent and active synapses, but AC8 plays an mportant role in resetting the balance of active to silent synapses after adaptation to strong activity. PMID: 18480272
16. Colocalizes with Orai1 and stromal interaction molecule 1 (STIM1) at the plasma membrane in lipid rafts PMID: 19171672
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Apical cell membrane. Cell junction, synapse. Cell projection, dendrite. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic density. Membrane raft. Membrane, coated pit. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, caveola.
蛋白家族：

Adenylyl cyclase class-4/guanylyl cyclase family
組織特異性：

Detected in brain cortex. Expressed in islet.
數據庫鏈接：

HGNC: 239

OMIM: 103070

KEGG: hsa:114

STRING: 9606.ENSP00000286355

UniGene: Hs.591859