Recombinant Human ATPase family AAA domain-containing protein 5 (ATAD5), partial

中文名稱：

Recombinant Human ATPase family AAA domain-containing protein 5(ATAD5) ,partial
貨號：

CSB-YP839400HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human ATPase family AAA domain-containing protein 5(ATAD5) ,partial
貨號：

CSB-EP839400HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human ATPase family AAA domain-containing protein 5(ATAD5) ,partial
貨號：

CSB-EP839400HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human ATPase family AAA domain-containing protein 5(ATAD5) ,partial
貨號：

CSB-BP839400HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human ATPase family AAA domain-containing protein 5(ATAD5) ,partial
貨號：

CSB-MP839400HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ATAD5
Uniprot No.：

Q96QE3
別名：

ATAD5; ATAD5_HUMAN; ATPase family AAA domain containing 5; ATPase family AAA domain-containing protein 5; C17orf41; chromosome fragility associated gene 1; Chromosome fragility-associated gene 1 protein; ELG1; Enhanced level of genomic instability 1 homolog; FRAG1
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis.
基因功能參考文獻：
1. Report rare ATAD5 missense mutations may contribute to genetic susceptibility breast cancer and epithelial ovarian carcinoma. PMID: 27045477
2. Authors discuss many functions of Elg1 protein as embryonic lethal when lost in mice, as a tumor suppressor in mice and humans, interacts with human Fanconi Anemia pathway and may contribute to some of the phenotypes associated with neurofibromatosis. [Review] PMID: 25795125
3. Elg1 has an important role in maintaining chromosome integrity by regulating PCNA levels on chromatin, thereby acting as a PCNA unloading factor. PMID: 23937667
4. ATAD5 regulates the cycle of DNA replication factories, probably through its PCNA-unloading activity. PMID: 23277426
5. loss-of-function mutations in mammalian Atad5 are sufficient to cause genomic instability and tumorigenesis. PMID: 21901109
6. Studies indicate that USP1 and ELG1 as regulators of PCNA ubiquitylation. PMID: 21640107
7. Human ELG1 protein is stabilized and localized to form foci at sites of stalled DNA replications that are different from DNA double strand breaks foci. PMID: 19755857
8. The Frag1 signal pathway, by linking replication stress surveillance with apoptosis induction, plays a central role in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. PMID: 15983387
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亞細胞定位：

Nucleus.
蛋白家族：

AAA ATPase family
數據庫鏈接：

HGNC: 25752

OMIM: 609534

KEGG: hsa:79915

STRING: 9606.ENSP00000313171

UniGene: Hs.528902