Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10), partial

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 10(ADAMTS10) ,partial
貨號：

CSB-YP862005HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 10(ADAMTS10) ,partial
貨號：

CSB-EP862005HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 10(ADAMTS10) ,partial
貨號：

CSB-EP862005HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 10(ADAMTS10) ,partial
貨號：

CSB-BP862005HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 10(ADAMTS10) ,partial
貨號：

CSB-MP862005HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ADAMTS10
Uniprot No.：

Q9H324
別名：

A disintegrin and metalloproteinase with thrombospondin motifs 10; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif; 10; A disintegrin-like and metallopeptidase with thrombospondin type 1 motif; 10; ADAM metallopeptidase with thrombospondin type 1 motif 10 ; ADAM TS10; ADAM-TS 10; ADAM-TS10; ADAMTS-10; Adamts10; ATS10_HUMAN; EC 3.4.24; WMS; WMS1; zinc metalloendopeptidase
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.
基因功能參考文獻：
1. Using siRNA, over-expression and mutagenesis, it was found ADAMTS6 inhibits and ADAMTS10 is required for focal adhesions, epithelial cell-cell junction formation, and microfibril deposition. PMID: 27779234
2. These findings support the Gly661Arg mutation of ADAMTS10 as the likely cause of POAG in beagles. PMID: 23422823
3. ADAMTS10 participates in microfibril biogenesis rather than in fibrillin-1 turnover PMID: 21402694
4. ADAMTS10 is a functional metalloprotease as demonstrated by cleavage of alpha2-macroglobulin PMID: 15355968
5. Expression in human colonic cell lines. PMID: 15358598
6. ADAMTS10 plays a major role in growth and in skin, lens, and heart development in humans. PMID: 15368195
7. infer that folding of the complex C-terminal ancillary domain is the rate-limiting step in biosynthesis of ADAMTS10, and that it (but not catalytic domain) is sensitive to subtle changes in efficiency of signal peptide cleavage. PMID: 18567016
8. Mutations in ADAMTS10 gene is not responsible for microspherophakia. PMID: 19696795
9. Homozygous mutation in ADAMTS10 causes lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. PMID: 19836009
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相關疾病：

Weill-Marchesani syndrome 1 (WMS1)
亞細胞定位：

Secreted, extracellular space, extracellular matrix.
組織特異性：

Widely expressed in adult tissues.
數據庫鏈接：

HGNC: 13201

OMIM: 277600

KEGG: hsa:81794

STRING: 9606.ENSP00000270328

UniGene: Hs.657508