Recombinant Human 3-hydroxybutyrate dehydrogenase type 2 (BDH2)

中文名稱：

Recombinant Human 3-hydroxybutyrate dehydrogenase type 2(BDH2)
貨號：

CSB-YP874814HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human 3-hydroxybutyrate dehydrogenase type 2(BDH2)
貨號：

CSB-EP874814HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human 3-hydroxybutyrate dehydrogenase type 2(BDH2)
貨號：

CSB-EP874814HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human 3-hydroxybutyrate dehydrogenase type 2(BDH2)
貨號：

CSB-BP874814HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human 3-hydroxybutyrate dehydrogenase type 2(BDH2)
貨號：

CSB-MP874814HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

BDH2
Uniprot No.：

Q9BUT1
別名：

3 hydroxybutyrate dehydrogenase type 2; 3-hydroxybutyrate dehydrogenase type 2; BDH 2; BDH2; BDH2_HUMAN; Dehydrogenase/reductase (SDR family) member 6; Dehydrogenase/reductase SDR family member 6; DHRS6; EFA6R; FLJ13261; Oxidoreductase ucpA; PRO20933; R beta hydroxybutyrate dehydrogenase; R-beta-hydroxybutyrate dehydrogenase; SDR15C1; Short chain dehydrogenase/reductase family 15C member 1; UCPA OR; UNQ6308
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區(qū)域：

1-245
氨基酸序列

MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM LAQKSGNIIN MSSVASSVKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARGNPEEARN DFLKRQKTGR FATAEEIAML CVYLASDESA YVTGNPVIID GGWSL
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria. Also acts as a 3-hydroxybutyrate dehydrogenase.
基因功能參考文獻：
1. High expression level of BDH2 is associated with esophageal squamous cell carcinoma. PMID: 26799587
2. intracellular expression in macrophages is downregulated by stress and inflammation PMID: 25762501
3. BDH2 expression is an independent poor prognostic factor for CN-AML, with an anti-apoptotic role. Patients with high BDH2 expression have relatively shorter overall survival and a low complete response rate. PMID: 23941109
4. Iron-mediated post-transcriptional regulation of hBDH2 controls mitochondrial iron homeostasis in human cells. PMID: 22527885
5. Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines. PMID: 21791085
6. DHRS6 is an orphan short chain dehydrogenase/ reductase enzyme PMID: 16380372
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亞細胞定位：

Cytoplasm.
蛋白家族：

Short-chain dehydrogenases/reductases (SDR) family
組織特異性：

Detected in liver (at protein level).
數(shù)據(jù)庫鏈接：

HGNC: 32389

KEGG: hsa:56898

STRING: 9606.ENSP00000296424

UniGene: Hs.124696