Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1), partial
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中文名稱：人PLCE1重組蛋白
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貨號：CSB-EP868386HU-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase epsilon-1; Pancreas-enriched phospholipase C; Phosphoinositide phospholipase C-epsilon-1; Phospholipase C-epsilon-1; PLC-epsilon-1; Plce1; PLCE1_HUMAN
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種屬：Homo sapiens (Human)
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蛋白長度：Partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downtream of AVIL to allow ARP2/3 complex assembly.
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基因功能參考文獻：
- PLCE1 polymorphism is associated with Gastric and esophageal cancer. PMID: 30202044
- Study found that rs2274223 A>G in PLCE1 was associated with lower PLCE1 gene expression and increased gastric cancer (GC) survival. These findings support PLCE1 rs2274223 as a potential prognostic biomarker for GC survival. PMID: 29983348
- we report the functional characterization of a four-nucleotide insertion/deletion variation (rs71031566 C----/CATTT) in PLCE1 that was associated with risk of developing esophageal squamous cell carcinoma PMID: 29106514
- knockdown of expression of PLCe inhibits Prostate cancer cells proliferation via the PTEN/AKT signaling pathway. PMID: 29330357
- the results of the multiple bioinformatic analysis contributes to a systematic understanding of the roles of PLCE1 in esophageal squamous cell carcinoma . PMID: 28849204
- these results showed that the knockdown of PLCE1 may play a vital role in the control of esophageal squamous cell carcinoma. PMID: 29238898
- Our results demonstrate that PLCE1 haplotypes (including rs2274223 and rs3765524) and expression combined with serum AFP level may predict postoperative outcome of HBV-related HCC patients. PMID: 28418898
- high expression of both PLCE1 and PRKCA is significantly associated with poor outcomes of the patients with esophageal cancers. PMID: 28402280
- rs10882379 and rs829232 SNPs in the PLCE1 gene may contribute to the esophageal squamous cell carcinoma (ESCC) susceptibility in Chinese Han population. Also the gene-gene and gene-environment interactions play a certain crucial role in the ESCC progression. PMID: 27061010
- No association between PLCE1 genotype and early viremia level in dengue patients. PMID: 28599625
- PLCE1 single-nucleotide polymorphism is associated with migraine. PMID: 27322543
- PLCE1 expression was found in the invasive carcinoma but not in the carcinoma in situ samples. Snail expression in the human ESCC samples significantly correlated with the PLCE1 protein level, and expression of Snail target genes in human esophageal cancer samples were also correlated with the PLCE1 abundance. PMID: 28147304
- results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity PMID: 27612188
- High PLC epsilon expression is associated with breast cancer. PMID: 28112359
- The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients PMID: 27907007
- Two novel putatively deleterious PLCE1 variants were identified in children with steroid-resistant nephrotic syndrome. PMID: 28476686
- PLC-epsilon is a novel regulator of endothelial cell inflammation and vascular endothelial permeability. PMID: 27371732
- Taken together, our data highlight the pivotal role of miR-1976 in the progression of NSCLC. Thus, miR-1976 may be a potential prognostic marker and of treatment relevance for NSCLC progression intervention. PMID: 27063799
- this study presents the impact of a single nucleotide transition at SNPs associated with DSS on differential protein binding patterns with PLCE1 and MICB genes and on protein structure modification and their possible role in the pathogenesis of dengue shock syndrome PMID: 27038471
- Study shows that PLCE1 Rs2274223 variation was significantly associated with colorectal cancer risk while rs3765524 did not. PMID: 27383248
- Data show that microRNA miR-145 was identified as a potent repressor of phospholipase C epsilon 1 (PLCE1) expression by directly targeting the 3' untranslated regions (3'UTR) of PLCE1. PMID: 26657507
- Data suggest the role of the phospholipase C epsilon-Protein kinase D-PEA15 protein-ribosomal S6 kinase-IkappaB-NF-kappa B pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon. PMID: 27053111
- Genetic Variants of PLCE1 Gene are not Associated with Colorectal Cancer. PMID: 26320491
- In conclusion, our results suggest that miR-328 suppresses the survival of EC cells by regulating PLCE1 expression, which might be a potential therapeutic method for EC. PMID: 26773497
- Our results suggested that STAT3 phosphorylation is involved in PLCe-mediated inflammatory cytokine release PMID: 26156799
- a significantly increased stomach cancer risk was associated with PLCE1 SNP rs2274223 in a Han Chinese population. PMID: 25658482
- Studied six SNP loci: (rs2279115 of BCL2 gene, rs804270 of NEIL2 gene, rs909253 of LTA gene, rs2294008 of PSCA gene, rs3765524 and rs10509670 of PLCE1 gene) to evaluate gastric cancer risk using magnetic nanoparticles and universal tagged arrays. PMID: 26554163
- This meta-analysis demonstrated that PLCE1 rs2274223 A > G polymorphism may be associated with increased susceptibility to cancer, especially for ESCC. PMID: 25614244
- PLCE1 gene rs2274223 polymorphism is associated with esophageal cancer PMID: 25854357
- variation in PLCE1 may be associated with GC risk in Kashmir Valley. PMID: 25434319
- The meta-analysis suggested that upregulated PLCE1 is significantly associated with an increased risk of tumor progression in esophageal squamous cell carcinoma and gastric cardia adenocarcinomas. PMID: 25520085
- PLCE1 rs2274223 polymorphism may be used as a potential biomarker for digestive tract cancer susceptibility particularly for esophageal squamous cell carcinoma and gastric cardia adenocarcinomas in the Chinese population. PMID: 24874112
- PLCE1 rs2274223 polymorphism is associated with esophageal cancer. PMID: 25422186
- The rs2274223 polymorphism in phospholipase C epsilon 1 was associated with an increased risk of esophageal squamous cell carcinoma in this Korean population PMID: 24152165
- Dysregulated PLCE1 mRNA expression was observed for both esophageal squamous cell carcinoma and gastric cancer PMID: 24867265
- Genetic variations in PLCE1 modulate risk of esophageal cancer in the high risk Kashmiri population. PMID: 24935391
- a new pathway for TRPC6 activation by Phospholipase C epsilon PMID: 25521631
- PLCE1 rs7922612CT + TT is associated with susceptibility of esophageal cancer. PMID: 25139097
- findings demonstrate that the presence of the G allele at rs2274223 of the PLCE1 gene may contribute to susceptibility to GC, especially cardia GC. PMID: 24985593
- PLCE1 gene silencing by RNAi resulted in decreased expression of cyclin D1. PMID: 25041015
- Meta-analysis suggested the PLCE1 rs2274223 might act as a cancer risk factor among all subjects, especially in the Chinese population and upper aerodigestive tract cancer. PMID: 24595086
- Data show that phospholipase C epsilon 1 (PLCE1) and liver X receptor-beta (LXR-beta) network interactions as important contributory factors for genetic predisposition in gallbladder cancer. PMID: 24863943
- NSCLC cells express high levels of PLCE1, which suppresses the expression of p53 in NSCLC cells. PMID: 24357048
- the PLCE1 rs2274223 A > G change might reduce gene expression and the variant genotype might contribute to the increased risk of colorectal cancer. PMID: 24496148
- Knockdown of PLCepsilon gene potently suppressed the nuclear factor kappa (NF-kappaB) signaling pathway. PMID: 24510280
- This meta-analysis provides strong statistical evidence for an elevated risk of EC associated with PLCE1 rs2274223 PMID: 24737582
- heterozygote of PLCE1 rs2274223 increases susceptibility to human papillomavirus infection in patients with esophageal carcinoma among the Kazakh populations. PMID: 24127316
- PKCalpha/beta is critical for PLCepsilon-mediated cancer cell invasion and migration PMID: 24316392
- Knockdown of PLCE1 markedly increased 9.26 folds of the expression of p53 and 13.8 folds of the frequency of apoptotic CP-C cells via modulating the p53 promoter methylation PMID: 24766303
- PLCepsilon1 shRNA depressed the in vitro and in vivo growth of gastric cancer cells by using MTT assay and tumor xenograft experiment. PMID: 24796667
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相關疾?。?/div>Nephrotic syndrome 3 (NPHS3)亞細胞定位：Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Cell projection, lamellipodium. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.組織特異性：Widely expressed. Expressed in podocytes.; [Isoform 1]: Broadly expressed and only absent in peripheral blood leukocytes.; [Isoform 2]: Specifically expressed in placenta, lung and spleen.數據庫鏈接：
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