Recombinant Horse Non-syndromic hearing impairment protein 5 homolog (DFNA5)

中文名稱：

Recombinant Horse Non-syndromic hearing impairment protein 5 homolog(DFNA5)
貨號：

CSB-YP771995HO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Horse Non-syndromic hearing impairment protein 5 homolog(DFNA5)
貨號：

CSB-EP771995HO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Horse Non-syndromic hearing impairment protein 5 homolog(DFNA5)
貨號：

CSB-EP771995HO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Horse Non-syndromic hearing impairment protein 5 homolog(DFNA5)
貨號：

CSB-BP771995HO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Horse Non-syndromic hearing impairment protein 5 homolog(DFNA5)
貨號：

CSB-MP771995HO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

GSDME
Uniprot No.：

Q7YS54
別名：

GSDME; DFNA5; Gasdermin-E; Non-syndromic hearing impairment protein 5 homolog) [Cleaved into: Gasdermin-E; N-terminal; GSDME-NT); Gasdermin-E; C-terminal; GSDME-CT)]
種屬：

Equus caballus (Horse)
蛋白長度：

full length protein
表達區域：

1-497
氨基酸序列

MFAKATRSFL REVDAEGDLI AVSNLNDSDK SQLLSLVTKK KRFWCWQRPK YQFLSVTLGD VLTEAQCLSP VVVESDFVKY EGKFENHVSG TIETALGKVK LNFGDKGLRE SQSSFGTLRK QEVDLQQLIR DSVERTINLK NPVLQQMLES KNEVLCILTQ KIVTTQKCVI SEHIQTEEKC GGMVGIKTKT VQVSVTKDEN IIKDASVALE IPAPTTIAYS VIELYVKLDG QFEFCLLRGK HGGFEHQRRS DIVFPDAGAL QDFPFWDVPD AGQGLPTPDG PLSVLKQGTR LLEKNFFPFV ELPEQHRTAL NTVLQAVLSD EELLAVLEQV CDDLVHSLSP PLAMLGELKP PHRQDLTAFL RLVGYRVQGG CPCLEDGVGS QKLFSTAYFL VSALAEMPDN AAALLGTCCK LQIIPALCHL LHAMSHDGVC DLEDPALAPL KDTERFGVAQ RLFASADINL ERVQSSVKAV TPLKDPSVLP LILYISLKGL CALGREH
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis.; Pore-forming protein produced by cleavage by CASP3 or granzyme B (GZMB), which converts non-inflammatory apoptosis to pyroptosis or promotes granzyme-mediated pyroptosis, respectively. After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. Binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate. Cleavage by CASP3 switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis. Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents. Exhibits bactericidal activity. Cleavage by GZMB promotes tumor suppressor activity by triggering robust anti-tumor immunity. Suppresses tumors by mediating granzyme-mediated pyroptosis in target cells of natural killer (NK) cells: cleavage by granzyme B (GZMB), delivered to target cells from NK-cells, triggers pyroptosis of tumor cells and tumor suppression. May play a role in the p53/TP53-regulated cellular response to DNA damage.
亞細胞定位：

[Gasdermin-E, N-terminal]: Cell membrane; Multi-pass membrane protein.; [Gasdermin-E]: Cytoplasm, cytosol.
蛋白家族：

Gasdermin family
數據庫鏈接：

KEGG: ecb:100033992

STRING: 9796.ENSECAP00000018779

UniGene: Eca.12871