Recombinant Guanine nucleotide-binding protein G (o) subunit alpha

中文名稱：

秀麗隱桿線蟲goa-1重組蛋白
貨號：

CSB-YP345954CXY
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

秀麗隱桿線蟲goa-1重組蛋白
貨號：

CSB-EP345954CXY
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

秀麗隱桿線蟲goa-1重組蛋白
貨號：

CSB-EP345954CXY-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

秀麗隱桿線蟲goa-1重組蛋白
貨號：

CSB-BP345954CXY
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

秀麗隱桿線蟲goa-1重組蛋白
貨號：

CSB-MP345954CXY
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

goa-1
Uniprot No.：

P51875
別名：

goa-1; C26C6.2Guanine nucleotide-binding protein G(o) subunit alpha
種屬：

Caenorhabditis elegans
蛋白長度：

Full Length of Mature Protein
表達區域：

2-354
氨基酸序列

GCTMSQEER AALERSRMIE KNLKEDGMQA AKDIKLLLLG AGESGKSTIV KQMKIIHESG FTAEDYKQYK PVVYSNTVQS LVAILRAMSN LGVSFGSADR EVDAKLVMDV VARMEDTEPF SEELLSSMKR LWGDAGVQDC FSRSNEYQLN DSAKYFLDDL ERLGEAIYQP TEQDILRTRV KTTGIVEVHF TFKNLNFKLF DVGGQRSERK KWIHCFEDVT AIIFCVAMSE YDQVLHEDET TNRMHESLKL FDSICNNKWF TDTSIILFLN KKDLFEEKIK KSPLTICFPE YSGRQDYHEA SAYIQAQFEA KNKSANKEIY CHMTCATDTT NIQFVFDAVT DVIIANNLRG CGLY
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. In the 1-cell embryo, probably together with gpa-16, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisions, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement. Involved in chemosensory responses to attractive and repellent odors detected by AWC and AWB sensory neurons, respectively. In ASER neurons, acts downstream of glr-3 to regulate cold avoidance behavior via calcium signaling, and it may also play a role in sensing cold in the intestine. Negatively regulates axon regeneration after injury downstream of the inhibitory compound arachidonoyl ethanolamide (AEA) by antagonizing the activation of the JNK pathway (mlk-1/mek-1/kgb-1). In neurons, may negatively regulate diacylglycerol (DAG) production mediated by egl-30 signaling cascade and thereby negatively regulates acetylcholine release. Couples to the muscarinic acetylcholine receptor gar-2 to negatively regulate cholinergic receptor activity in the presence of high levels of acetylcholine in ventral cord motor neurons. Plays a role in the navigational capacity of sperm and the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. Involved in egg-laying and in regulating dopamine-mediated locomotion. Most likely couples to the dopamine receptors dop-2 and dop-3 to positively regulate the dopamine-mediated suppression of crh-1/CREB1 transcription factor activation in cholinergic SIA neurons in the presence of food.
基因功能參考文獻：
1. Exogenous arachidonoyl ethanolamide inhibits axon regeneration via the Goalpha subunit GOA-1, which antagonizes the Gqalpha subunit EGL-30. PMID: 23072806
2. Following food deprivation G protein alpha(o) is activated via RIC-8 activation. PMID: 21832186
3. Our results suggest that EGL-47 regulates egg laying by activating Galpha(o) in the hermaphrodite-specific motor neurons to inhibit their activity. PMID: 15456826
4. The stravation response is fully dependent on the subsequent activation of the G alpha(q) ortholog EGL-30. PMID: 17021164
5. These results suggest that Galpha signaling and LET-99 control centration by regulating polarized actomyosin contraction. PMID: 17893243
6. Goa-1 Goalpha and let-60 Ras act in parallel to gpc-1 in olfactory pathways. PMID: 19189947
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蛋白家族：

G-alpha family, G(i/o/t/z) subfamily
組織特異性：

Expressed in the ASER neuron and the intestine.
數據庫鏈接：

KEGG: cel:CELE_C26C6.2

STRING: 6239.C26C6.2.2

UniGene: Cel.17339