Recombinant Gelsolin-like protein 1 (gsnl-1)

中文名稱：

秀麗隱桿線蟲gsnl-1重組蛋白
貨號：

CSB-YP630334CXY
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

秀麗隱桿線蟲gsnl-1重組蛋白
貨號：

CSB-EP630334CXY
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

秀麗隱桿線蟲gsnl-1重組蛋白
貨號：

CSB-EP630334CXY-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

秀麗隱桿線蟲gsnl-1重組蛋白
貨號：

CSB-BP630334CXY
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

秀麗隱桿線蟲gsnl-1重組蛋白
貨號：

CSB-MP630334CXY
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

gsnl-1
Uniprot No.：

Q21253
別名：

gsnl-1; K06A4.3Gelsolin-like protein 1
種屬：

Caenorhabditis elegans
蛋白長度：

full length protein
表達區域：

1-475
氨基酸序列

MGGTSLDPAL AEIGKKNGLL VWRINKFVLE PVPEVDHGVF YIGDAYIALY QKYDGCWDVH FWLGKNASTD EIGVAAIKTV EIDDSLGGIP TQHREIQNYE SPLFLSYFPD GIRYVSGGYE SGYRHVDDQF KNWKPHLFHC KGKRNVRCTE VECEVNSLNL GDVFILDLGK DLYVWMPPES GRLERIKGMA RAKNIADHER MGIPKVHILD DVEWDNDSTF WSYFGGVSSV RKVSKGKDDD DNYWKRLTEQ ITLWKVSDAS GAAKVSMVSQ GENIRKEQLD PKDAFILDAI NGGIFVWIGH ECTLEERSKA LIWGQNYLKQ HHLPRWTQVT RVLESAESTQ FTQWFRDWVD EKKKNTFTPL LFQVSDESGL LHVEEIANFT QEDLDGDDVM ILDALNSIYV WVGANANANE KKEALNTAKL YLEKDKLPRH KKTAIDTIFQ GKEPPTFKKF FPSWDDNLFK NEVRSVQNMR RLLFH
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development.
基因功能參考文獻：
1. GSNL-1 acts downstream of the cell death pathway in synapse elimination. Cleavage of GSNL-1 by CED-3 induces synapse elimination. PMID: 26074078
2. Calcium-sensitive activity and conformation of Caenorhabditis elegans gelsolin-like protein 1 are altered by mutations in the first gelsolin-like domain. PMID: 21840993
3. GSNL-1 is a novel member of the gelsolin family of actin regulatory proteins with four gelsolin-like repeats PMID: 18640981
4. Both conserved and different utilization of G domains between C. elegans GSNL-1 and mammalian gelsolin for actin regulatory functions. PMID: 20392036
亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

Villin/gelsolin family
數據庫鏈接：

KEGG: cel:CELE_K06A4.3

STRING: 6239.K06A4.3

UniGene: Cel.3126