Recombinant Drosophila melanogaster Protein sine oculis (so)

中文名稱：

黑腹果蠅so重組蛋白
貨號：

CSB-YP632924DLU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅so重組蛋白
貨號：

CSB-EP632924DLU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅so重組蛋白
貨號：

CSB-EP632924DLU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅so重組蛋白
貨號：

CSB-BP632924DLU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅so重組蛋白
貨號：

CSB-MP632924DLU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

so
Uniprot No.：

Q27350
別名：

so; CG11121; Protein sine oculis
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

full length protein
表達區域：

1-416
氨基酸序列

MLQHPATDFY DLAAANAAAV LTARHTPPYS PTGLSGSVAL HNNNNNNSST SNNNNSTLDI MAHNGGGAGG GLHLNSSSNG GGGGGVVSGG GSGGRENLPS FGFTQEQVAC VCEVLQQAGN IERLGRFLWS LPQCDKLQLN ESVLKAKAVV AFHRGQYKEL YRLLEHHHFS AQNHAKLQAL WLKAHYVEAE KLRGRPLGAV GKYRVRRKFP LPRTIWDGEE TSYCFKEKSR SVLRDWYSHN PYPSPREKRD LAEATGLTTT QVSNWFKNRR QRDRAAEHKD GSTDKQHLDS SSDSEMEGSM LPSQSAQHQQ QQQQQQHSPG NSSGNNNGLH QQQLQHVAAE QGLQHHPHQP HPASNIANVA ATKSSGGGGG GGVSAAAAAQ MQMPPLTAAV AYSHLHSVMG AMPMTAMYDM GEYQHL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for visual system development. May transcriptionally regulate genes necessary for optic lobe invagination and Bolwig's nerve formation.
基因功能參考文獻：
1. By removing gene function in differentiating cells, the study shows that so is dispensable for larval photoreceptor differentiation, but is required for differentiation during pupal development. PMID: 27257739
2. mapping of So-enriched regions throughout the genome in third instar larval eye discs; study found 7,566 So-enriched regions, which map to approximately 5,952 genes, including previously characterized So targets in the eye PMID: 24586968
3. atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers PMID: 24247006
4. Loss of So in the eye disc caused ectopic antenna development in the eye. PMID: 22912416
5. Data suggest that during early phases of eye development, So and Optix function, in part, to repress the transcription of non-retinal selector genes, thereby allowing induction of the retina to proceed. PMID: 22318629
6. Results describe the roles of sine oculis and glass proteins in the development of the Drosophila corpus cardiacum. PMID: 15385159
7. A novel dominant-negative mutation within the six domain of the conserved eye specification gene so inhibits eye development. PMID: 15704100
8. genome-wide search and have thereby been able to identify eyeless as well as the signalling gene hedgehog as putative targets of so PMID: 15901665
9. different cofactors likely mediate unique functions of Sine oculis and Optix during the development of the fly eye PMID: 15937930
10. dominant mutant phenotype is primarily due to an alteration in binding properties of the Sine oculis protein during eye development PMID: 16125693
11. Study shows that distinct cis-regulatory elements control atonal expression specifically in the eye and that the Retinal Determination factors Eyeless and Sine oculis function as direct regulators. PMID: 17108002
12. expression of so on its own is sufficient to induce eye development within non-retinal tissues PMID: 17137572
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亞細胞定位：

Nucleus.
蛋白家族：

SIX/Sine oculis homeobox family
組織特異性：

In developing embryos, expressed in the eye disk epithelium, bolwig's organ and the optic lobe primordium at areas of invagination. In adults, present in photoreceptor cells in the apical regions of the retina, and in optic lobes.
數據庫鏈接：

KEGG: dme:Dmel_CG11121

STRING: 7227.FBpp0089177

UniGene: Dm.4727