Recombinant Drosophila melanogaster Protein commissureless (comm), partial

中文名稱：

Recombinant Drosophila melanogaster Protein commissureless(comm),partial
貨號：

CSB-YP632575DLU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Drosophila melanogaster Protein commissureless(comm),partial
貨號：

CSB-EP632575DLU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Drosophila melanogaster Protein commissureless(comm),partial
貨號：

CSB-EP632575DLU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Drosophila melanogaster Protein commissureless(comm),partial
貨號：

CSB-BP632575DLU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Drosophila melanogaster Protein commissureless(comm),partial
貨號：

CSB-MP632575DLU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

comm
Uniprot No.：

Q24139
別名：

comm; CG17943Protein commissureless 1; Protein commissureless
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Controls axon guidance across the CNS midline by preventing the delivery of Robo to the growth cone.
基因功能參考文獻：
1. PRRG4 could re-localize hRobo1 from the cell surface, suggesting that PRRG4 is a functional homologue of Comm. Comm is required for axon guidance and synapse formation in the fly, so PRRG4 could contribute to the autistic symptoms of WAGR by disturbing either of these processes in the developing human brain. PMID: 28859078
2. Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline. PMID: 12050141
3. the ability of Comm to localise intracellularly and hence regulate Robo surface levels requires sequences in both the N-terminal and transmembrane domains PMID: 14550530
4. These studies provide insights into the specific regulation of dNedd4-mediated ubiquitination of Comm and subsequent internalization of Comm or the Comm/Roundabout complex, critical for CNS and muscle development. PMID: 16531238
5. dNedd4 and ubiquitination are required for Commissureless endocytosis and proper neuromuscular synaptogenesis. PMID: 17074801
6. findings show Fra mediates canonical chemoattraction in response to netrin & it functions independently of netrin to activate commissureless transcription, allowing attraction to be coupled to downregulation of repulsion in precrossing commissural axons PMID: 19325078
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亞細胞定位：

Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
蛋白家族：

Commissureless family
數據庫鏈接：

KEGG: dme:Dmel_CG17943

STRING: 7227.FBpp0305237

UniGene: Dm.2546