Recombinant Drosophila melanogaster MOB kinase activator-like 1 (mats)

中文名稱：

黑腹果蠅mats重組蛋白
貨號：

CSB-YP842576DLU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅mats重組蛋白
貨號：

CSB-EP842576DLU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅mats重組蛋白
貨號：

CSB-EP842576DLU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅mats重組蛋白
貨號：

CSB-BP842576DLU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅mats重組蛋白
貨號：

CSB-MP842576DLU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

mats
Uniprot No.：

Q95RA8
別名：

mats; CG13852; MOB kinase activator-like 1; Mob as tumor suppressor protein 1; Dmob1; Mps one binder kinase activator-like 1
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

full length protein
表達區域：

1-219
氨基酸序列

MDFLFGSRSS KTFKPKKNIP EGTHQYDLMK HAAATLGSGN LRNAVALPDG EDLNEWVAVN TVDFFNQINM LYGTITEFCT EETCGIMSAG PKYEYHWADG LTVKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFHSSAKT ILKRLFRVYA HIYHQHFTEV VTLGEEAHLN TSFKHFIFFV QEFNLIERRE LAPLQELIDK LTAKDERQI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Coactivator of Warts (Wts) kinase in the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki)oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Mats is essential for early development and is required for proper chromosomal segregation in developing embryos.
基因功能參考文獻：
1. Mob as tumor suppressor is regulated by bantam microRNA through a feedback loop for tissue growth control PMID: 24016667
2. These results support a model in which the plasma membrane is an important site of action for Mats tumor suppressor to control tissue growth and organ size. PMID: 19913529
3. described growth inhibitory functions for a Mob superfamily protein, termed Mats; loss of Mats function results in increased cell proliferation, defective apoptosis, and induction of tissue overgrowth [Mats] PMID: 15766530
4. mats regulation in development was studied. PMID: 18472003
亞細胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytosol. Cell membrane. Note=Colocalizes with wts and cyclin E at the centrosome.
蛋白家族：

MOB1/phocein family
組織特異性：

Ubiquitously expressed at low levels in developing tissues (at protein level).
數據庫鏈接：

KEGG: dme:Dmel_CG13852

STRING: 7227.FBpp0083624

UniGene: Dm.3572