Recombinant Death-associated protein kinase dapk-1 (dapk-1), partial

中文名稱：

Recombinant Death-associated protein kinase dapk-1(dapk-1) ,partial
貨號：

CSB-YP528598CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Death-associated protein kinase dapk-1(dapk-1) ,partial
貨號：

CSB-EP528598CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Death-associated protein kinase dapk-1(dapk-1) ,partial
貨號：

CSB-EP528598CXY-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Death-associated protein kinase dapk-1(dapk-1) ,partial
貨號：

CSB-BP528598CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Death-associated protein kinase dapk-1(dapk-1) ,partial
貨號：

CSB-MP528598CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

dapk-1
Uniprot No.：

O44997
別名：

dapk-1; mor-3; tag-119; K12C11.4Death-associated protein kinase dapk-1; EC 2.7.11.1
種屬：

Caenorhabditis elegans
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Negative regulator of epidermal barrier repair and innate immune responses to wounding. The role in epidermal tissue integrity and wound healing is established through the inhibition of epidermal microtubule stability, possibly via the negative regulation of the microtubule minus-end binding protein ptrn-1. In epidermis, prevents expression of specific unc-44 isoforms probably by promoting nuclear localization of pinn-1, which in turn may affect sydn-1-ssup-72-mediated regulation of alternative polyadenylation of unc-44 mRNA. Appears to act downstream of or in parallel to muscarinic signaling in the regulation of autophagy.
基因功能參考文獻：
1. loss of sydn-1 blocks ectopic expression of neuronal ankyrin and suppresses epidermal morphology defects of dapk-1; effects of sydn-1 are mediated by ssup-72 autonomously in the epidermis PMID: 28087624
2. studies highlight the prominence of DAPK and Pin1/PINN-1 as conserved mediators of cell death processes in diverse scenarios of neurodegeneration PMID: 25899010
3. The death-associated protein kinase DAPK-1 acts as a negative regulator of wound closure. PMID: 22100061
4. Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in homeostasis. Review. PMID: 19878311
5. Overexpression of DAPK-1 represses innate immune responses to needle wounding PMID: 19164535
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亞細胞定位：

Cytoplasm, cytosol. Cytoplasm, cytoskeleton.
蛋白家族：

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
組織特異性：

Expressed in epidermis, muscles and neurons.
數(shù)據(jù)庫鏈接：

KEGG: cel:CELE_K12C11.4

STRING: 6239.K12C11.4

UniGene: Cel.18457