Recombinant Danio rerio Signal peptide, CUB and EGF-like domain-containing protein 2 (scube2), partial

中文名稱：

斑馬魚scube2重組蛋白
貨號：

CSB-YP705065DIL
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

斑馬魚scube2重組蛋白
貨號：

CSB-EP705065DIL
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

斑馬魚scube2重組蛋白
貨號：

CSB-EP705065DIL-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

斑馬魚scube2重組蛋白
貨號：

CSB-BP705065DIL
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

斑馬魚scube2重組蛋白
貨號：

CSB-MP705065DIL
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

scube2
Uniprot No.：

Q5G872
別名：

scube2; you; Signal peptide; CUB and EGF-like domain-containing protein 2; Protein You
種屬：

Danio rerio (Zebrafish) (Brachydanio rerio)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.
基因功能參考文獻：
1. Emilin3 modulates the availability of hedgehog ligands by interacting with the permissive factor Scube2 in the notochord sheath PMID: 24131633
2. Data show that knocking down the function of all three scube genes scube1, scube2 and scube3 simultaneously phenocopies a complete loss of Hedgehog (HH) signal transduction in the embryo. PMID: 22609552
3. positional cloning and functional studies demonstrate that You is a novel extracellular component of the Hedgehog pathway in vertebrates(You gene) PMID: 15660164
4. Scube2 can modulate the long-range action of Bmp-dependent Hedgehog signaling in the neural tube and somites. PMID: 15753045
5. Scube2 may act during Hedgehog signal transduction prior to, or during, receipt of the Hedgehog signal at the plasma membrane PMID: 16626681
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亞細胞定位：

Secreted. Cell surface.
數據庫鏈接：

KEGG: dre:503728

STRING: 7955.ENSDARP00000054365

UniGene: Dr.150435