Recombinant Danio rerio E3 ubiquitin-protein ligase RNF168 (rnf168)

中文名稱：

斑馬魚rnf168重組蛋白
貨號：

CSB-YP745841DIL
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

斑馬魚rnf168重組蛋白
貨號：

CSB-EP745841DIL
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

斑馬魚rnf168重組蛋白
貨號：

CSB-EP745841DIL-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

斑馬魚rnf168重組蛋白
貨號：

CSB-BP745841DIL
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

斑馬魚rnf168重組蛋白
貨號：

CSB-MP745841DIL
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

rnf168
Uniprot No.：

Q7T308
別名：

rnf168; zgc:64185; E3 ubiquitin-protein ligase rnf168; EC 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase rnf168
種屬：

Danio rerio (Zebrafish) (Brachydanio rerio)
蛋白長度：

full length protein
表達區(qū)域：

1-474
氨基酸序列

MPPVSEVDRG PVEESSGGLK RSDCVCPVCL EIFLEPVTLP CMHTFCKPCF LETVDKSNMC CPLCRKRVST WARLNSRNKT LVNMELWRRI QDAFPSQCER RVQGIDDDEE AVMIPKPRVC QPGELRKEYE DQISKLVEEK RALEEAERRA SEEYIQRLLA EEEERLEEER RRREEQQLEN DEKLARLLSL ELNSGPASES TCNIKPAEAT PAKKKPSVGD IEKFLRPVPH RQPSSSDSSP DSSLMANKEN ILSPPKPLSA LSAEDCGKLT VHMLECNGKP STSSFNPSTS EHTFVFNTPK SSSVKRKSSE IELQSEVDLH SKRPCALLRF DSSSEDSPFL SEVAVHEEAL RSRWQQEEED RRLALRIQKE LDRENSVDRR KGSADSYQLR QKNTSVSTTT SPDVEGTKKG SNTTTAKNCT GRRGEEKTEK RLSGTTPGKR PGVKTPVSST AVSSTVKKGT KQTTLTEMFP NMGS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of tp53bp1 and brca1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
亞細胞定位：

Nucleus.
蛋白家族：

RNF168 family
數(shù)據(jù)庫鏈接：

KEGG: dre:334081

STRING: 7955.ENSDARP00000037364

UniGene: Dr.7739