Recombinant Chicken Cellular tumor antigen p53 (TP53)

中文名稱：

雞TP53重組蛋白
貨號：

CSB-YP024077CH
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

雞TP53重組蛋白
貨號：

CSB-EP024077CH
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

雞TP53重組蛋白
貨號：

CSB-EP024077CH-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

雞TP53重組蛋白
貨號：

CSB-BP024077CH
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

雞TP53重組蛋白
貨號：

CSB-MP024077CH
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TP53
Uniprot No.：

P10360
別名：

TP53; Cellular tumor antigen p53; Tumor suppressor p53
種屬：

Gallus gallus (Chicken)
蛋白長度：

Full length protein
表達區域：

1-367
氨基酸序列

MAEEMEPLLE PTEVFMDLWS MLPYSMQQLP LPEDHSNWQE LSPLEPSDPP PPPPPPPLPL AAAAPPPLNP PTPPRAAPSP VVPSTEDYGG DFDFRVGFVE AGTAKSVTCT YSPVLNKVYC RLAKPCPVQV RVGVAPPPGS SLRAVAVYKK SEHVAEVVRR CPHHERCGGG TDGLAPAQHL IRVEGNPQAR YHDDETTKRH SVVVPYEPPE VGSDCTTVLY NFMCNSSCMG GMNRRPILTI LTLEGPGGQL LGRRCFEVRV CACPGRDRKI EEENFRKRGG AGGVAKRAMS PPTEAPEPPK KRVLNPDNEI FYLQVRGRRR YEMLKEINEA LQLAEGGSAP RPSKGRRVKV EGPQPSCGKK LLQKGSD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
基因功能參考文獻：
1. Protein p53 occurs at key stages of development: in the esophagus during the remodeling of esophageal glands, in the proventriculus during the differentiation of the epithelium of the mucosa and in the gizzard during the formation of tubular glands. PMID: 24068480
2. p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes. PMID: 21447558
3. Results suggest that extensive deletions are efficient mechanisms of TP53 inactivation, occurring as early events during the immortalization of v-src-transformed chicken cells. PMID: 15723564
4. An initial down-regulation of p53 allowed the SC-2 cells to bypass senescence. The inactivation of p53, and consequently p21WAF1, likely contributed to the SC-2 cells becoming a fully immortal cell line. PMID: 16813656
5. results suggest that the short form of p53 could play a role in the initiation of apoptosis induced by the chemotherapeutic compound, and that the regulation of its expression may be important for the maintenance of transformation status. PMID: 16820712
6. Nitric oxide-induced cell death operates through p53-independent pathways, including a mitochondrial apoptotic pathway in chick embryo cardiomyocytes. PMID: 17630850
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

P53 family
數據庫鏈接：

KEGG: gga:396200

UniGene: Gga.706