Recombinant Chicken Cathelicidin-2 (CATHL2)

中文名稱：

Recombinant Chicken Cathelicidin-2(CATHL2)
貨號：

CSB-YP644158CH
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Chicken Cathelicidin-2(CATHL2)
貨號：

CSB-EP644158CH
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Chicken Cathelicidin-2(CATHL2)
貨號：

CSB-EP644158CH-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Chicken Cathelicidin-2(CATHL2)
貨號：

CSB-BP644158CH
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Chicken Cathelicidin-2(CATHL2)
貨號：

CSB-MP644158CH
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CATHL2
Uniprot No.：

Q2IAL7
別名：

CATHL2; CMAP27Cathelicidin-2; CATH-2; Fowlicidin-2; Myeloid antimicrobial peptide 27
種屬：

Gallus gallus (Chicken)
蛋白長度：

Cytoplasmic domain
表達區域：

123-154
氨基酸序列

LVQRGRFG RFLRKIRRFR PKVTITIQGS ARFG
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.
基因功能參考文獻：
1. L-CATH-2, D-CATH-2 and LL-37 can modulate the immune response of primary chicken immune cells by increasing mannose receptor expression, antigen presentation, endocytosis and neutralizing LPS-induced cytokine production and as a result augment activation of the adaptive immune system. PMID: 28715682
2. CAMP and CATHB1 were significantly up-regulated in bone marrow cells, whereas the expression of CATH3 did not differ significantly between chicken bone marrow cells and chicken embryonic fibroblasts. PMID: 26908883
3. Here, recombinant fowlicidin-2 was successfully produced by E. coli recombinant expression system.The recombinant peptide exhibited high antibacterial activity against the Gram-positive and Gram-negative bacteria, and even drug-resistant strains. PMID: 25641948
4. chicken cathelicidin (CATH)-2 strongly enhances DNA-induced activation of both chicken and mammalian macrophages because of enhanced endocytosis of DNA-CATH-2 complexes. PMID: 26378074
5. results indicate that bacterial toxins induce chCATH-B1 gene expression in the chicken BF and the peptide expressed in the organ would act against pathogenic microorganisms not only directly but also indirectly by attracting mast cells PMID: 24984089
6. the carboxyl-terminal peptide of chCATH-B1 has broad antimicrobial activity against Gram-positive and Gram-negative bacteria. chCATH-B1 expression is restricted to the secretory epithelial cell neighbors of the M cells. PMID: 17827276
7. microbicidal activity of CATH-2(myeloid antimicrobial peptide 27) & expression in heterophilic granulocytes at the site of infection in Salmonella-challenged animals, indicate cathelicidins may play an important role in preventing bacterial infections PMID: 19187966
8. Results indicate that core elements within mature CATH-2 can be identified that are linked to antibacterial and/or immunomodulatory activities. PMID: 19524300
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亞細胞定位：

Secreted.
蛋白家族：

Cathelicidin family
組織特異性：

Detected in trachea, lung, proventriculus, duodenum, jejunum, ileum, caeca, colon, caecal tonsil, bursa of Fabricius, kidney, ovary, testis, thymus, liver, spleen, bone marrow, skin, uropygial gland, muscle and brain.
數據庫鏈接：

KEGG: gga:420407

STRING: 9031.ENSGALP00000030658

UniGene: Gga.9531