Recombinant Chicken Bloom syndrome protein homolog (BLM), partial

中文名稱：

Recombinant Chicken Bloom syndrome protein homolog(BLM) ,partial
貨號：

CSB-YP864261CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Chicken Bloom syndrome protein homolog(BLM) ,partial
貨號：

CSB-EP864261CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Chicken Bloom syndrome protein homolog(BLM) ,partial
貨號：

CSB-EP864261CH-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Chicken Bloom syndrome protein homolog(BLM) ,partial
貨號：

CSB-BP864261CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Chicken Bloom syndrome protein homolog(BLM) ,partial
貨號：

CSB-MP864261CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

BLM
Uniprot No.：

Q9I920
別名：

BLMBloom syndrome protein homolog; EC 3.6.4.12; RecQ helicase homolog
種屬：

Gallus gallus (Chicken)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair. Negatively regulates sister chromatid exchange (SCE). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds DNA. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction.
基因功能參考文獻：
1. first enzymatic characterization of chicken BLM and its N-terminal domain PMID: 28338731
2. BLM is assembled from dimer into hexamer, and also, the stable DHBN dimer can be dissociated upon ATP hydrolysis. Thus, the structural and biochemical characterizations of N-terminal domains will provide new insights into how the N-terminal domain affects the structural and functional organization of the full BLM molecule. PMID: 28228481
3. Disruption of the BLM gene in ATM-null DT40 cells (a B-lymphocyte cell line)does not exacerbate either phenotype. PMID: 14985700
4. These data indicate that BLM and Top3alpha execute the dissolution of sister chromatids. PMID: 16880537
5. These data suggest that Fbh1 acts in parallel with Bloom helicase to control recombination-mediated double-strand-break repair at replication blocks and to reduce the frequency of crossover. PMID: 17283053
6. Results show that Blm promotes HR between diverged sequences through a novel ATPase-independent mechanism. PMID: 19661064
顯示更多

收起更多
亞細(xì)胞定位：

Nucleus.
蛋白家族：

Helicase family, RecQ subfamily
數(shù)據(jù)庫鏈接：

KEGG: gga:415577

STRING: 9031.ENSGALP00000013422

UniGene: Gga.1914