Recombinant Centruroides noxius Potassium channel toxin gamma-KTx 1.1 (ERG1)

中文名稱：

Recombinant Centruroides noxius Potassium channel toxin gamma-KTx 1.1(ERG1)
貨號：

CSB-YP768193DRB
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Centruroides noxius Potassium channel toxin gamma-KTx 1.1(ERG1)
貨號：

CSB-EP768193DRB
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Centruroides noxius Potassium channel toxin gamma-KTx 1.1(ERG1)
貨號：

CSB-EP768193DRB-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Centruroides noxius Potassium channel toxin gamma-KTx 1.1(ERG1)
貨號：

CSB-BP768193DRB
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Centruroides noxius Potassium channel toxin gamma-KTx 1.1(ERG1)
貨號：

CSB-MP768193DRB
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

N/A
Uniprot No.：

Q86QT3
別名：

Potassium channel toxin gamma-KTx 1.1; Ergtoxin; CnErg1; CnErgTx1; ErgTx; ErgTx1
種屬：

Centruroides noxius (Mexican scorpion)
蛋白長度：

full length protein
表達區域：

21-62
氨基酸序列

DRDSCVDKSR CAKYGYYQEC QDCCKNAGHN GGTCMFFKCK CA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Blocks human and rat Kv11.1/KCNH2/ERG1 and Kv11.3/KCNH7/ERG3, as well as rat (but not human) Kv11.2/KCNH6/ERG2 by binding to channel outer vestibule (S5P domain) with a 1:1 stoichiometry. Inhibition data are the following: hERG1 (reversible, IC(50)~7 nM), rERG1 (reversible, Kd=6.8 nM), rERG2 (irreversible, Kd=2.8 nM), hERG3 (irreversible, Kd=4.05 nM) and rERG3 (reversible, Kd=38.1 nM) potassium channels. The toxin potency is not affected by elevating potassium ion concentration from 2 to 98 mM. This toxin only blocks channels in a closed state. At high toxin concentrations, block of Kv11.1/KCNH2/ERG1 macroscopic current is incomplete (93.5%). This suggests a kinetic mechanism model with two different states of toxin-channel binding (T+C=TC*=TC; in the TC* state, the toxin binds the channel but does not occlude the pore, whereas in the TC state the toxin binds and occludes the pore). In this model, incomplete block is explained by the relatively fast dissociation rate from the blocked channel conformation (TC) relative to the rate of conversion of the toxin-channel encounter complex (TC*) to the blocked channel conformation (TC).
亞細胞定位：

Secreted.
蛋白家族：

Ergtoxin family, Gamma-KTx 1 subfamily
組織特異性：

Expressed by the venom gland.