Recombinant Bovine TIR domain-containing adapter molecule 2 (TICAM2)
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中文名稱：牛TICAM2重組蛋白
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貨號：CSB-EP642612BO-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：TICAM2
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Uniprot No.：
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別名：TICAM2; TRAM; TIR domain-containing adapter molecule 2; TICAM-2; TRIF-related adapter molecule
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種屬：Bos taurus (Bovine)
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蛋白長度：Full Length of Mature Protein
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表達區域：2-232
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氨基酸序列GIGKSKMDP CHLSVPWGKS QSVDTSQSHH MSDSKQSEEI SLHGDAVCSS TAEMPAEEQE GVEERPEEDT EEEVFLKFVI LHAEEDTGEA LRVQSLLEND FGIKPGIIFA EMPCGRQHLQ NLDDAVNGSA WTILLLTENF LRDTWCKFQF YSSLMNSVNR QHKYNSVIPM RPLNNPLPRE RTPFALRTIN ALEEESRGFP TQVERIFQES VYRIQQAIWK ETRNTVQRQS VA
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria.
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亞細胞定位：Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome. Late endosome. Cell projection, phagocytic cup.
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