Recombinant Bovine SHC-transforming protein 1 (SHC1)

中文名稱：

牛SHC1重組蛋白
貨號：

CSB-YP612560BO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

牛SHC1重組蛋白
貨號：

CSB-EP612560BO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

牛SHC1重組蛋白
貨號：

CSB-EP612560BO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

牛SHC1重組蛋白
貨號：

CSB-BP612560BO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

牛SHC1重組蛋白
貨號：

CSB-MP612560BO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SHC1
Uniprot No.：

Q0IIE2
別名：

SHC1; SHC-transforming protein 1; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1
種屬：

Bos taurus (Bovine)
蛋白長度：

full length protein
表達區域：

1-473
氨基酸序列

MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV ISTIGQAFEL RFKQYLRNPP RLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL GGVVDMRLRE GALPGAARPT PPSAQTPSHL GATLPVGQPA GGDPEARRQM PPPPPSSGRE LFDDPSYVNV QNLDKARQAG AGAGPPNPTI NGSAPRDLFD MKPFEDALRM PPPPQSTAMA EQLRGEPWFH GKLSRREAEA LLQVNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG VVRTKDHRFE SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
基因功能參考文獻：
1. The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos. PMID: 24475205
2. Studied p66Shc levels, redox state, and developmental potential in early bovine embryos. p66Shc content was increased by either high (20%) O(2) culture or H(2)O(2) treatment, and significantly dec'd by antioxidant polyethylene glycol-conjugated catalase. PMID: 23109234
3. p66shc, but not p53, is significantly more abundant in an embryo population that exhibits higher frequencies of embryo arrest. PMID: 17382201
4. p66Shc is involved in the regulation of embryo development specifically in mediating early cleavage arrest and facilitating development to the blastocyst stage for in vitro produced bovine embryos PMID: 18047664
5. These results support a model in which Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammatory signaling. PMID: 18606845
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亞細胞定位：

Cytoplasm.
數據庫鏈接：

KEGG: bta:507196

STRING: 9913.ENSBTAP00000026432

UniGene: Bt.4279