Recombinant Bovine E3 ubiquitin-protein ligase TRIM17 (TRIM17)

中文名稱：

牛TRIM17重組蛋白
貨號：

CSB-YP647187BO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

牛TRIM17重組蛋白
貨號：

CSB-EP647187BO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

牛TRIM17重組蛋白
貨號：

CSB-EP647187BO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

牛TRIM17重組蛋白
貨號：

CSB-BP647187BO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

牛TRIM17重組蛋白
貨號：

CSB-MP647187BO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

TRIM17
Uniprot No.：

Q2T9Z0
別名：

TRIM17; E3 ubiquitin-protein ligase TRIM17; EC 2.3.2.27; RING-type E3 ubiquitin transferase TRIM17; Tripartite motif-containing protein 17
種屬：

Bos taurus (Bovine)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-475
氨基酸序列

MDAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRECI QLTWEKARGQ KKRRKRKGSF PCPECRELSP QRNLRPNRLL TKVAEMVRQH PSPQSRDLCQ VHRELLKLFC EDDQRPICII CRESQEHRPH RVVPIEEAVQ EYKLKLEEDM EHLREEMMKT EKLQAKEEHT LAEWQEKVKE RRERIMVEFE KMGLFLMEEK QRLLQALKKE EEETVAKLQE STASLKQQSH SLERLLLQLE DRNEHTPLQM LQDMKGLLSR KSSLSVQYPE ATSIMLKTIC RVPGQIEVLK SFQEDVVPDP STAYPYLLLY ESRQRRYLST PMDGTPCGKD RFLAYPCAVG QEIYSSGRHY WEVGMNLTGD ALWALGVCRD NVSRRNRVPK SPENGFWVVQ LCKGKRYAPA AFPPTPVTLA EPPSHMGIFL DFEAGELAFY NANDGSHLHS YTQPAFPGPL QPFFCLGAPK SGQMVISTVT LWVKG
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation. Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation. Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1. Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells. Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1.
亞細(xì)胞定位：

Cytoplasm. Lysosome.
蛋白家族：

TRIM/RBCC family
數(shù)據(jù)庫鏈接：

KEGG: bta:618634

STRING: 9913.ENSBTAP00000024853

UniGene: Bt.91974