Recombinant Ataxin-3 homolog (atx-3)

中文名稱：

Recombinant Ataxin-3 homolog(atx-3)
貨號(hào)：

CSB-YP519441CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Ataxin-3 homolog(atx-3)
貨號(hào)：

CSB-EP519441CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Ataxin-3 homolog(atx-3)
貨號(hào)：

CSB-EP519441CXY-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Ataxin-3 homolog(atx-3)
貨號(hào)：

CSB-BP519441CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Ataxin-3 homolog(atx-3)
貨號(hào)：

CSB-MP519441CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

atx-3
Uniprot No.：

O17850
別名：

atx-3; F28F8.6Ataxin-3 homolog; EC 3.4.19.12; Machado-Joseph disease-like protein
種屬：

Caenorhabditis elegans
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-317
氨基酸序列

MSKDDPINSI FFEHQEAALC AQHALNMLLQ DALYKWQDLR DLAIQMDKME QQILGNANPT PGRSENMNES GYFSIQVLEK ALETFSLKLT NIENPAMVDY KNNPLTARAY ICNLREHWFV LRKFGNQWFE LNSVNRGPKL LSDTYVSMFL HQVSSEGYSI FVVQGVLPRS DADDLISLCP VVPPKVTPKK EQKLEKVMTK FFNTVGKRLG GGSGAPPDSQ EEKDLAIAFA MSMETKDGSE VSRSSAEIDE ENLRKAIELS QAPGPSEPAE IPLLTRSRSS TPPGASEPFS NAEQQRRDRQ KFLERFEKKK EERNDEK
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription.
基因功能參考文獻(xiàn)：
1. ATX-3 is a Machado-Joseph disease deubiquitylase that couples longevity and proteostasis PMID: 21317884
2. ataxin-3 has a role in regulating core sets of genes involved in the ubiquitin-proteasome pathway, structure/motility, and signal transduction PMID: 17234717
亞細(xì)胞定位：

Cytoplasm. Nucleus. Nucleus, nucleolus.
組織特異性：

Expressed in germline (at protein level). Expressed in spermatheca, pharynx, dorsal and ventral cords, some head neurons, hypodermis, body wall muscles and coelomocytes.
數(shù)據(jù)庫(kù)鏈接：

KEGG: cel:CELE_F28F8.6

STRING: 6239.F28F8.6.1

UniGene: Cel.6510