1. Study find that WUSCHEL, a key gene required for apical meristem maintenance, is a cytokinin-dependent type-B ARABIDOPSIS RESPONSE REGULATORS target gene, demonstrating the importance of the cytokinin transcription factor network in shoot development. PMID: 29686312
2. Cytokinin signaling in the rib meristem acts through the transcriptional regulatory domains, the acidic domain and the WUSCHEL-box, to stabilize the WUS protein. PMID: 29659567
3. ARR12 binds to the promoter of WUS. PMID: 28681564
4. WUS is regulated by a balance between positive regulation by cytokinin and negative regulation by CLAVATA protein. PMID: 27208247
5. Dynamic expression reveals a two-step patterning of WUS and CLV3 during axillary shoot meristem formation in Arabidopsis PMID: 28399422
6. results provide important insights into the molecular framework for cytokinin-directed shoot regeneration and reveal a two-step mechanism for de novo activation of WUS. PMID: 28389585
7. there is a positive feedback regulation between WUS and OBE3 that contributes to shoot meristem homeostasis PMID: 27196372
8. The interplay between cytokinin signaling, WUS/CLV feedback loop and boundary signals can account for positioning of the WUS expression in the process of Arabidopsis thaliana shoot apical meristem patterning. PMID: 26872130
9. The branching ovules of the mutant resemble those of some fossil gymnosperms, implicating BEL1 and HD-ZIPIII genes as players in the evolution of the unbranched ovule form in extant angiosperms. PMID: 26700684
10. The stem cell niche in Arabidopsis copes with environmental hazards by enhancing the IRES-dependent translation of WUS mRNA under the control of the AtLa1 protein. PMID: 25764476
11. stem cell specification pathway is normally repressed by the activity of the HD-zip III transcription factors PHABULOSA (PHB), PHAVOLUTA (PHV) and CORONA (CNA). PMID: 26011610
12. In the floral meristem, the binding of AG to WUS is reduced in top1a-2, which results in reduced H3K27me3 levels at WUS and prolonged WUS expression, and consequently loss of floral determinacy. PMID: 25070639
13. Data indicate that the stem cell inducing transcription factor WUSCHEL (WUS) moves to the stem cells via plasmodesmata in a highly regulated fashion and that this movement is required for WUS function. PMID: 25246576
14. AtWus may therefore increase the differentiation potential of cotton callus by triggering the auxin transport and signaling pathways. PMID: 24498119
15. GRP23 expression can be activated by WUS. PMID: 24086632
16. HECATE1 (HEC1) is a target of WUS and that it contributes to SAM function by promoting stem cell proliferation, while antagonizing niche cell activity. HEC1 represses the stem cell regulators WUS and CLAVATA3 (CLV3) PMID: 24576426
17. Strong upregulation of WUS in the inflorescence meristem leads to ectopic expression of the AGAMOUS homeotic gene to a level that switches cell fate from floral meristem founder cell to carpel founder cell. PMID: 24496620
18. Results suggest that ASL11/LBD15 affects cellular differentiation in the SAM and regulates WUS expression. PMID: 23397191
19. Cytokinin treatment induces the expression of the shoot meristematic gene WUSCHEL (WUS) in converting LRP (cLRP) within 24-30 h, and WUS is required for lateral root primorida(LRP)--> New shoot meristems (SMs) conversion. PMID: 23181633
20. AG directly represses WUS expression by binding to the WUS locus and recruiting, directly or indirectly, PcG that methylates histone H3 Lys-27 at WUS. PMID: 22028461
21. DNA methylation and histone modifications regulate de novo shoot regeneration by modulating WUS expression and auxin signaling. PMID: 21876682
22. Studies indicate that the shoot and root meristems are promoted by WUSCHEL (WUS) and WOX5. PMID: 22076631
23. the WUS protein, after being synthesized in cells of the organizing center, migrates into the central zone, where it activates CLV3 transcription by binding to its promoter elements PMID: 21979915
24. WUSCHEL-mediated cellular feedback network imparts robustness to stem cell homeostasis. PMID: 21406977
25. WUS produces severe phenotypes by disrupting the development of somatic embryos on the maturation medium and inhibiting germination. PMID: 20424847
26. New function for WUS in mediating the balance between differentiation and non-differentiating cells of the peripheral zone. PMID: 20876644
27. WUS expression is controlled by the ratio of cytokinin with auxin. PMID: 20514542
28. CLAVATA1 is part of a negative feedback regulation of WUSCHEL protein in Arabidopsis thaliana. PMID: 20493817
29. Our results demonstrate that WUS acts mainly as a repressor and that its function changes from that of a repressor to that of an activator in the case of regulation of the expression of AG. PMID: 19897670
30. Ultrapetal1 negatively regulates WUSCHEL to establish floral meristem determinacy. PMID: 15342527
31. results suggest that overexpression of WUS could trigger cell pluripotence and reestablish new meristems from differentiated tissues PMID: 15952065
32. The homeobox gene WUSCHEL (WUS) is expressed in the organizing center underneath the stem cells and integrates regulatory information from several pathways to define the boundaries of the stem cell niche. PMID: 15980263
33. data indicate that ARR genes might negatively influence meristem size and that their repression by WUS might be necessary for proper meristem function PMID: 16372013
34. Detailed characterization of a semidominant roa allele revealed an essential role for the conserved C-terminal domain that mediates an interaction between WUS and two members of a small family of corepressor-like proteins in Arabidopsis. PMID: 16461579
35. facilitates high cytokinin activity in the shoot apical meristem PMID: 16877025
36. WUS expression is initiated very early during anther development in the precursor cells of the stomium and terminates just before the stomium cells enter terminal differentiation PMID: 17027956
37. Importantly, both WOX5 and WUS maintain stem cells in either a root or shoot context. PMID: 17429400
38. Data suggest that, by limiting WUS expression to the organizing center, BARD1 regulates shoot apical meristem organization and maintenance. PMID: 18591352
39. WUS-dependent organising centre signalling to the stem cells is promoted by AGO1 and subsequently maintained by a provascular ZLL-dependent signalling pathway. PMID: 18653559
40. Establishment of auxin gradients and PIN1-mediated polar auxin transport are essential for WUS induction and somatic embryogenesis. PMID: 19453451
41. Data show that cytokinin-induced WUSCHEL expression occurs through both CLAVATA-dependent and CLAVATA-independent pathways. PMID: 19717465

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KEGG: ath:AT2G17950

STRING: 3702.AT2G17950.1

UniGene: At.51