Recombinant Caenorhabditis elegans Alpha-tubulin N-acetyltransferase 1 (mec-17)

中文名稱：

秀麗隱桿線蟲mec-17重組蛋白
貨號：

CSB-YP526136CXY
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

秀麗隱桿線蟲mec-17重組蛋白
貨號：

CSB-EP526136CXY
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

秀麗隱桿線蟲mec-17重組蛋白
貨號：

CSB-EP526136CXY-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

秀麗隱桿線蟲mec-17重組蛋白
貨號：

CSB-BP526136CXY
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

秀麗隱桿線蟲mec-17重組蛋白
貨號：

CSB-MP526136CXY
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

mec-17
Uniprot No.：

O45100
別名：

mec-17; F57H12.7Alpha-tubulin N-acetyltransferase 1; Alpha-TAT 1; TAT 1; EC 2.3.1.108; Mechanosensory abnormality protein 17
種屬：

Caenorhabditis elegans
蛋白長度：

full length protein
表達區域：

1-262
氨基酸序列

MQVDADLRPI LGPQLVRLDP MRVKQLQDPI VYEAIDNLAK LSAHCLQLRT PLTTCEKLIN SDSTLYLSWK YDEEEKVSRL MGFAKVGRKK LFLYDSQMQT YEGEILCLLD FYVHFSCQRQ GVGQQILDYM FSQEHTEPYQ LALDNPSVTL LGFMSQKYGL IKPVWQNTNF VVFEELFLAL SAENGIEKPP PDGWRRPMTP RRLGTGMTDT RWLQHAVSGH QSKGNAMAAP VDADMTPQGA LSNRAHQAKA RKAHILSSKP LW
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for the maintenance of touch receptor neurons and possibly other type of neurons involved in locomotion.
基因功能參考文獻：
1. Loss of MEC-17 affects microtubule dynamics, axonal transport and causes axonal degeneration. PMID: 24373971
2. MEC-17 allows the production of 15-protofilament microtubules in touch receptor neurons. PMID: 22658602
3. Study shows that MEC-17, a protein related to the Gcn5 histone acetyltransferases4 and required for the function of touch receptor neurons in Caenorhabditis elegans. PMID: 20829795
蛋白家族：

Acetyltransferase ATAT1 family
組織特異性：

Expressed solely in touch receptor neurons.
數據庫鏈接：

KEGG: cel:CELE_F57H12.7

STRING: 6239.F57H12.7

UniGene: Cel.12810