Histone H1.0 Recombinant Monoclonal Antibody
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中文名稱：組蛋白 H1.0重組抗體
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貨號：CSB-RA010087A0HU
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規(guī)格：￥1320
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CSB-RA010087A0HU 是一款針對核心連接組蛋白H1.0設(shè)計的高特異性科研抗體。該靶蛋白作為染色質(zhì)結(jié)構(gòu)的關(guān)鍵調(diào)控因子，通過參與核小體間連接維持基因組穩(wěn)定性，并在細胞分化、基因沉默及表觀遺傳調(diào)控中發(fā)揮重要作用。本產(chǎn)品經(jīng)ELISA平臺嚴格驗證，展現(xiàn)優(yōu)異的抗原結(jié)合能力與批次間一致性，可精準識別天然構(gòu)象的Histone H1.0蛋白。其重組單克隆抗體技術(shù)確保低交叉反應(yīng)性和高重復性，適用于染色質(zhì)動態(tài)分析、表觀遺傳修飾研究、基因表達譜解析等基礎(chǔ)科研領(lǐng)域，尤其在探索細胞周期調(diào)控、干細胞分化機制及腫瘤發(fā)生相關(guān)染色質(zhì)重塑過程中具有重要應(yīng)用價值，為核蛋白功能研究和表觀遺傳學模型構(gòu)建提供可靠工具。
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Uniprot No.：
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基因名：H1F0
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別名：H1 histone family member 0 antibody; H1(0) antibody; H10 antibody; H10_HUMAN antibody; h1f0 antibody; H1FV antibody; Histone H1'' antibody; Histone H1(0) antibody; Histone H1.0 antibody; Histone H10 antibody; Histone H5 antibody; MGC5241 antibody; N-terminally processed antibody
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反應(yīng)種屬：Human
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免疫原：A synthesized peptide
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：1C7
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
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基因功能參考文獻：
- H1.X moves more rapidly than other linker histones in vivo Domain swapping between H1.0 and H1.X suggests that the globular domain (GD) and C-terminal domain (CTD) of H1.X independently contribute to the dynamic behavior of H1.X. PMID: 27528617
- this study shows that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. PMID: 27708074
- The N-terminal domain contributes toward the differential chromatin binding affinity, whereas the C-terminal domain contributes toward distinct nucleosomal interface of isotypes H10 and H1c. PMID: 22334665
- nuclear transport of H1 histones requires a heterodimeric nuclear import receptor PMID: 12080050
- H1(0)histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1(0) expression. PMID: 12149419
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亞細胞定位：Nucleus. Chromosome. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
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蛋白家族：Histone H1/H5 family
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數(shù)據(jù)庫鏈接：
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