ZG16B Recombinant Monoclonal Antibody

說明書

中文名稱：

ZG16B重組抗體
貨號：

CSB-RA836195MA1HU
規格：

￥1320
圖片：
The Binding Activity of Human ZG16B with Anti-ZG16B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ZG16B (CSB-MP836195HU) at 2 μg/mL can bind Anti-ZG16B recombinant antibody, the EC₅₀ is 24.13-46.04 ng/mL.

The Binding Activity of Macaca fascicularis ZG16B with Anti-ZG16B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ZG16B (CSB-MP4727MOV) at 2 μg/mL can bind Anti-ZG16B recombinant antibody , the EC₅₀ is 20.15-28.98 ng/mL.
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產品詳情
產品評價
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靶點詳情

產品詳情

產品描述：

CSB-RA836195MA1HU為ZG16B重組單克隆抗體，靶向人源ZG16B（Zymogen Granule Protein 16B）蛋白，該蛋白在消化酶分泌調控中發揮重要作用，參與胰腺酶原顆粒的形成及腸道免疫調節過程。本產品經過嚴格的ELISA平臺驗證，展現出優異的結合特異性和檢測靈敏度，不同批次間具有高度穩定性，可精準識別天然構象及重組表達的ZG16B靶蛋白。適用于體外檢測ZG16B蛋白表達水平，支持消化系統功能研究、分泌通路機制解析以及腸道屏障相關疾病的分子機理探索，為研究腸道微生物互作、細胞粘附調控及外分泌細胞功能提供可靠工具。該抗體適用于樣本中ZG16B的定量檢測與定性分析，廣泛應用于細胞模型、組織裂解液等實驗體系的基礎科研領域。
Uniprot No.：

Q96DA0
基因名：

ZG16B
別名：

ZG16B; Zymogen granule protein 16 homolog B; UNQ773/PRO1567
反應種屬：

Human, Macaca fascicularis
免疫原：

Recombinant Human ZG16B protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

hIgG1
純化方式：

Affinity-chromatography
克隆號：

6E5
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

基因功能參考文獻：
1. we conclude that the PAUF is a powerful and multifunctional promoter of tumor growth through increase and functional activation of myeloid-derived suppressor cells PMID: 27322081
2. Mouse DCPP1 is a multifunctional promoter of tumor growth through functional activation of pancreatic cancer cells, suggesting it to be an ortholog of human PAUF. PMID: 28988106
3. Our results suggest that PAUF has tumour-promoting functions in oral squamous cell carcinoma PMID: 27706833
4. High PAUF expression is associated with resistance to gemcitabine in pancreatic cancer. PMID: 26684804
5. PAUF mediated dendritic cell activation and immune stimulation are dependent on TLR4 PMID: 26336989
6. constitutive suppression of PAUF sensitized Bxpc3 pancreatic cancer cells to oncolytic parvovirus H-1 infection PMID: 25727013
7. PAUF rs12373A>C polymorphisms are associated with colorectal cancer. PMID: 25079514
8. PAUF-siRNA inhibited the proliferation of colorectal cancer cells, promoted their apoptosis and induced G0/G1 cell cycle arrest. At the same time, PAUF-siRNA inhibited the invasion, adhesion and migration of the tumor cells. PMID: 23677445
9. new possibilities for PAUF's role in the pathogenesis of angiogenesis-dependent diseases PMID: 22907431
10. activation of SIRT1 inhibited the proliferation of pancreatic cancer -PAUF cells by down-regulation of cyclin-D1, a target molecule of beta-catenin. PMID: 22640743
11. PAUF-mediated FAK activation plays an important role in pancreatic cancer progression. PMID: 21464589
12. PAUF can up-regulate and stabilize beta-catenin via a novel pattern of phosphorylation, thereby contributing to the rapid proliferation of pancreatic cancer cells. PMID: 21196815
13. Data demonstrate that the host salivary protein CSP-1 (HRPE773 GenBank AAQ89380.1) binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface. PMID: 20858015
14. the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site. PMID: 21110947
15. PAUF is a mammalian lectin normally found in plant lectins. PAUF induces extracellular signal-regulated kinase phosphorylation and activates the IKK-b-mediated TPL2/MEK/ERK signaling pathway through TLR2. PMID: 20802527
16. Findings indicate that PAUF enhances the metastatic potential of pancreatic cancer cells, at least in part, by upregulating CXCR4 expression. PMID: 19784070
17. Bioinformatic analysis identified a putative human CSP-1/Dcpp ortholog, HRPE773, expressed predominantly in human salivary tissue, that shows 31% amino acid identity and 45% amino acid similarity to the mouse Dcpp query sequence. PMID: 16954406
18. pancreatic adenocarcinoma up-regulated factor was secreted into the culture medium of pancreatic adenocarcinoma up-regulated factor-overexpressing Chinese hamster ovary cells, had an apparent molecular mass of approximately 25 kDa, and was N-glycosylated PMID: 19302292
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亞細胞定位：

Secreted.
蛋白家族：

Jacalin lectin family
數據庫鏈接：

HGNC: 30456

KEGG: hsa:124220

STRING: 9606.ENSP00000371715

UniGene: Hs.105887

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