STX3 Recombinant Monoclonal Antibody

說明書

中文名稱：

STX3 Recombinant Monoclonal Antibody
貨號：

CSB-RA280045A0HU
規格：

￥1320
圖片：
Overlay Peak curve showing A431 cells stained with CSB-RA280045A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.
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靶點詳情

產品詳情

Uniprot No.：

Q13277
基因名：

STX3
別名：

Syntaxin-3, STX3, STX3A
反應種屬：

Human
免疫原：

A synthesized peptide from human STX3 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

20C10
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, FC

推薦稀釋比：

Application	Recommended Dilution
FC	1:50-1:200

Protocols：

ELISA Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Potentially involved in docking of synaptic vesicles at presynaptic active zones.
基因功能參考文獻：
1. Stx3S is differentially expressed in normal human tissues, during epithelial cell polarization, and in breast cancer versus normal breast tissue. Inhibition of endogenous Stx3S expression alters the expression of cancer-associated genes and promotes cell proliferation. PMID: 29475951
2. mechanism study shows that STX3 binds to PTEN and increases PTEN ubiquitination and degradation, thus leading to activation of the PI3K-Akt-mTOR signaling. Therefore, STX3 promotes the growth of breast cancer cells by regulating the PTEN-PI3K-Akt-mTOR signaling. PMID: 29408595
3. we report for the first time a missense mutation of a novel lens specific gene STX3 in a phenotype associating autosomal recessive congenital cataract and intellectual disability. PMID: 25358429
4. GLUT5 required an interaction cascade of Rab11, Myo5B, Slp4a, Munc18-2, and Vamp7 with Stx3. PMID: 26553929
5. Rab11a-knockdown cells displayed mislocalization of STX3 and the presentation of microvilli in the basolateral compartment PMID: 25673875
6. the secretion of IL-1alpha, IL-1beta, IL-12b, and CCL4 occurs during gelatinase degranulation, a process controlled by STX3. PMID: 25548252
7. The results showed that there was reduction in aggregation propensity of syntaxin-3 with point mutation at Val286. PMID: 25630102
8. hcmv-miR-US33-5p-mediated inhibition of HCMV DNA synthesis and of viral replication are specifically mediated by down-regulation of STX3 expression. PMID: 25583387
9. loss of STX3 function causes variant microvillus inclusion disease PMID: 24726755
10. syntaxin3 has a latent prosurvival function and is involved in maintenance of homeostasis in epidermal keratinocytes PMID: 24171760
11. In insulin secretion, SYN-3 plays a role in the mediation of newcomer SG exocytosis and SG-SG fusion that contributes to biphasic GSIS. PMID: 23132338
12. siRNA knockdown (KD) of syntaxins 3 and 4 in HeLa cells reduced cell surface expression of alpha5beta1 and alpha3beta1 integrins PMID: 21720706
13. STX-3 and SNAP-23 are crucial for the release of all chemokines in mature human mast cells PMID: 21981832
14. These results demonstrate a function for STX3 in human cytomegalovirus morphogenesis, and unravel a new role for this SNARE protein in late endosomes/lysosomes compartments. PMID: 21371234
15. syntaxin 3 interacts with CFTR in vivo. PMID: 20844248
16. Munc18b is functionally coupled to the assembly of exocytic SNARE complexes and increases exocytosis by interacting with the N-peptide and closed-conformation C-terminus of Stx3, thereby neutralizing the secretion-inhibitory effect of this SNARE. PMID: 20695848
17. Data show that the BCG phagosome is relatively depleted in LAMP-2, NPC1, flotillin-1, vATPase, and syntaxin 3. PMID: 19815536
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亞細胞定位：

Membrane; Single-pass type IV membrane protein.
蛋白家族：

Syntaxin family
數據庫鏈接：

HGNC: 11438

OMIM: 600876

KEGG: hsa:6809

STRING: 9606.ENSP00000338562

UniGene: Hs.180711

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