SLC27A4 Recombinant Monoclonal Antibody
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中文名稱：SLC27A4重組抗體
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貨號：CSB-RA235828A0HU
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規格：￥1320
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圖片：
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Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Mouse brain tissue
All lanes: SLC27A4 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 73, 27 kDa
Observed band size: 42 kDa
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其他：
產品詳情
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產品描述：CSB-RA235828A0HU SLC27A4重組單克隆抗體是針對溶質載體家族27成員4（SLC27A4/FATP4）設計的高特異性科研試劑。SLC27A4作為脂肪酸轉運蛋白家族成員，在長鏈脂肪酸的跨膜轉運、脂質代謝調控及能量穩態維持中發揮關鍵作用，其表達異常與代謝紊亂、皮膚屏障功能障礙等研究領域密切相關。該抗體經多種實驗驗證，適用于ELISA和Western Blot技術平臺，在WB實驗中推薦使用1:500-1:2000稀釋范圍，能夠特異性識別目標蛋白，且在不同物種來源的樣本中均表現出低背景和高信噪比特性。該產品可廣泛應用于細胞或組織中SLC27A4蛋白的定量檢測、脂肪酸代謝相關信號通路研究、肥胖或糖尿病等代謝疾病模型的分子機制解析，以及藥物靶點篩選中的功能驗證實驗，為脂質代謝、細胞生物學及營養生理學等基礎研究提供可靠工具。本產品僅限科學研究用途。
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Uniprot No.：
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基因名：
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別名：Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4), SLC27A4, ACSVL4 FATP4
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反應種屬：Human, Mouse
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免疫原：A synthesized peptide derived from human SLC27A4
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：11A1
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產品提供形式：Liquid
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應用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Probably involved in fatty acid transport across the blood barrier. Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones.
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基因功能參考文獻：
- SLC27A4 gene mutation is responsible in the diagnosis of ichthyosis prematurity syndrome in a premature infant. PMID: 26341232
- expand the mutational repertory of FATP4 with three undescribed pathogenic mutations in two families PMID: 27168232
- The results have interesting implications that SLC27A4/ATG4B complex might be conducive to the occurrence of autophagy in human cancer cells, which is meaningful investigations toward the aim of developing autophagy-targeting drugs and have significant values in clinical application. PMID: 26662804
- no association between placental expression and maternal body mass index PMID: 27016784
- we resequenced the SLC27A3 and SLC27A4 genes using 267 autism spectrum disorders(ASD) patient and 1140 control samples and detected 47 and 30 variants for the SLC27A3 and SLC27A4, revealing that they are highly polymorphic with multiple rare variants. PMID: 26548558
- We describe two siblings with ichthyosis prematurity syndrome and report a recurrent homozygous mutation (c.1430T>A) that is predicted to lead to a p.Val477Asp substitution in fatty acid transport protein 4. PMID: 24889544
- the cell surface protein CD36/FAT directly facilitates fatty acid transport across the plasma membrane, whereas the intracellular acyl-CoA synthetases FATP4 and ACSL1 enhance fatty acid uptake indirectly by metabolic trapping PMID: 24503477
- the clinical implications of defects in these transporters and relevant animal models, including the FATP4 animal models and ichthyosis prematurity syndrome, a congenital ichthyosis caused by FATP4 deficiency. [review] PMID: 24120574
- FATP4, ichthyin and TGM1 interact in lipid processing essential for maintaining the epidermal barrier function PMID: 23290633
- FATP4 plays crucial roles in the development and maturation of both sebaceous and meibomian glands, as well as in the formation and composition of sebum PMID: 23271751
- FATP1 and FATP4 proteins perform different functional roles in handling long chain fatty acids in skeletal muscle PMID: 22235293
- even though hypoxia regulates the expression of FATP2 and FATP4 in human trophoblasts, mouse Fatp2 and Fatp4 are not essential for intrauterine fetal growth. PMID: 22028793
- Mutation in FATP4 in a patient with self-healing congenital verruciform hyperkeratosis.( PMID: 20815031
- findings propose fatty acid transport protein 4 as a candidate gene for the insulin resistance syndrome PMID: 14715877
- intra-pair correlations revealed that FATP4 expression was significantly up-regulated in acquired obesity." PMID: 15168018
- Data suggest that endogenous FATP4 does not function to translocate fatty acids across the plasma membrane, but functions more as a very long-chain acyl-CoA synthetase. PMID: 17901542
- Mutations in FATP4 gene cause the ichthyosis prematurity syndrome. PMID: 19631310
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相關疾病：Ichthyosis prematurity syndrome (IPS)
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亞細胞定位：Endoplasmic reticulum membrane; Multi-pass membrane protein.
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蛋白家族：ATP-dependent AMP-binding enzyme family
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組織特異性：Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tiss
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