MMAE&MMAF Recombinant Monoclonal Antibody
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中文名稱：MMAE&MMAF重組抗體
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貨號：CSB-RA903890I1m
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規(guī)格：￥3000
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圖片：
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The Binding Activity of Disitamab vedotin (Synonyms: RC48) with Anti-MMAE&MMAF antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Disitamab vedotin (Synonyms: RC48) at 2 μg/mL can bind Anti-MMAE&MMAF antibody, the EC50 is 3.523 to 5.356 ng/mL. -
The Binding Activity of Depatuxizumab mafodotin (Synonyms: ABT-414) with Anti-MMAE&MMAF antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Depatuxizumab mafodotin (Synonyms: ABT-414) at 2 μg/mL can bind Anti-MMAE&MMAF antibody, the EC50 is 3.022 to 4.198 ng/mL. -
The Binding Activity of Disitamab vedotin (Synonyms: RC48) and Depatuxizumab mafodotin (Synonyms: ABT-414) with Anti-MMAE&MMAF antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Disitamab vedotin (Synonyms: RC48) and Depatuxizumab mafodotin (Synonyms: ABT-414) at 2 μg/mL can bind Anti-MMAE&MMAF antibody, the EC50 is 3.523 to 5.356 ng/mL and 3.022 to 4.198 ng/mL, respectively. -
The purity of MMAE&MMAF was greater than 95% as determined by SEC-HPLC
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：MMAE&MMAF重組單克隆抗體是針對抗體藥物偶聯(lián)物（ADC）中關(guān)鍵細(xì)胞毒性成分開發(fā)的檢測工具，適用于酶聯(lián)免疫吸附實(shí)驗(yàn)（ELISA）平臺。該抗體特異性識別單甲基奧瑞他汀E（MMAE）和單甲基奧瑞他汀F（MMAF）兩種微管聚合抑制劑，這兩種小分子化合物通過破壞微管網(wǎng)絡(luò)抑制細(xì)胞分裂，廣泛應(yīng)用于靶向抗癌藥物的開發(fā)。經(jīng)嚴(yán)格驗(yàn)證，該抗體在1:5000至1:50000的寬泛稀釋范圍內(nèi)保持穩(wěn)定檢測性能，具備高靈敏度和低交叉反應(yīng)特性，可精準(zhǔn)檢測復(fù)雜生物樣本中MMAE/MMAF的微量存在。其應(yīng)用場景涵蓋ADC藥物的體外效價評估、藥物偶聯(lián)效率分析以及藥代動力學(xué)研究等領(lǐng)域，為科研人員提供可靠的定量檢測方案，特別適用于藥物開發(fā)過程中關(guān)鍵質(zhì)量屬性的監(jiān)控及作用機(jī)制研究，是生物制藥領(lǐng)域基礎(chǔ)研究的重要工具。
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基因名：MMAE; MMAF
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別名：MMAE, Monomethyl auristatin E, SGD-1010, Vedotin; MMAF, Monomethylauristatin F
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反應(yīng)種屬：Human
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免疫原：MMAE-BSA
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：IgG2b
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純化方式：Affinity-chromatography
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克隆號：25G12B5
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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推薦稀釋比：
Application Recommended Dilution ELISA 1:5000-1:50000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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