LTBR Recombinant Monoclonal Antibody
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中文名稱：LTBR Recombinant Monoclonal Antibody
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貨號(hào)：CSB-RA013227MA1HU
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規(guī)格：￥1320
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圖片：
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The Binding Activity of Human LTBR with Anti-LTBR Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LTBR(CSB-MP013227HU1) at 2 μg/mL can bind Anti-LTBR recombinant antibody. The EC50 is 0.6450-0.8200 ng/mL. -
The Binding Activity of Human LTBR with Anti-LTBR Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LTBR (CSB-YP013227HU1) at 2 μg/mL can bind Anti-LTBR recombinant antibody. The EC50 is 0.5282-0.6120 ng/mL.
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：LTBR Recombinant Monoclonal Antibody（CSB-RA013227MA1HU）是針對(duì)淋巴毒素β受體（LTBR）研發(fā)的高特異性抗體，靶向于腫瘤壞死因子受體超家族成員LTBR。該受體在淋巴器官發(fā)育、免疫穩(wěn)態(tài)調(diào)控及炎癥反應(yīng)中發(fā)揮重要作用，參與B細(xì)胞分化、生發(fā)中心形成等關(guān)鍵生物學(xué)過程。本產(chǎn)品經(jīng)ELISA驗(yàn)證顯示優(yōu)異的檢測(cè)性能，推薦使用稀釋比例為1:5000至1:50000，可精準(zhǔn)識(shí)別天然構(gòu)象下的LTBR抗原表位，適用于體外實(shí)驗(yàn)中的靶蛋白定量分析與功能研究。其高批次間穩(wěn)定性和低交叉反應(yīng)性特點(diǎn)，為免疫學(xué)、腫瘤微環(huán)境及自身免疫性疾病機(jī)制研究提供可靠工具，可應(yīng)用于受體-配體互作研究、免疫細(xì)胞信號(hào)通路解析或炎癥相關(guān)分子網(wǎng)絡(luò)構(gòu)建等科研場(chǎng)景，助力于探索LTBR在免疫調(diào)節(jié)及病理狀態(tài)中的分子調(diào)控機(jī)制。
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Uniprot No.：
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基因名：
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別名：CD18 antibody; D12S370 antibody; LT beta R antibody; LTBETAR antibody; Ltbr antibody; Lymphotoxin B receptor antibody; Lymphotoxin beta receptor (TNFR superfamily; member 3) antibody; Lymphotoxin beta receptor antibody; Lymphotoxin-beta receptor antibody; TNF R III antibody; TNF-RIII antibody; TNFCR antibody; TNFR RP antibody; TNFR superfamily member 3 antibody; TNFR-III antibody; TNFR2 RP antibody; TNFR2RP antibody; TNFR3 antibody; TNFRII antibody; TNFRRP antibody; TNFRSF 3 antibody; TNFRSF3 antibody; TNR3_HUMAN antibody; Tumor necrosis factor C receptor antibody; Tumor necrosis factor receptor 2 related protein antibody; Tumor necrosis factor receptor 2-related protein antibody; Tumor necrosis factor receptor superfamily member 3 antibody; Tumor necrosis factor receptor superfamily member 3 precursor antibody; Tumor necrosis factor receptor type III antibody
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反應(yīng)種屬：Human
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免疫原：Recombinant Human LTBR protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：hIgG1
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純化方式：Affinity-chromatography
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克隆號(hào)：7G6
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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推薦稀釋比：
Application Recommended Dilution ELISA 1:5000-1:50000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
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基因功能參考文獻(xiàn)：
- the lymphotoxin beta receptor (LTbetaR) to elicit the fast release of NF-kappaB inducing kinase (NIK) from the receptor complex leading to non-canonical NF-kappaB signaling. PMID: 29329668
- these results suggest that the LTBR rs12354 polymorphism might be associated with the spontaneous resolution of hepatitis B virus infection PMID: 28575727
- LTBR and BCLAF1 showed higher DNA methylation percentages in the marsupialized OKCs, but this difference did not affect gene expression (P > .05). PMID: 28864293
- membrane-bound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor 2 (CXCR2), is involved in type B EAE development PMID: 27820602
- LIGHT and LTBR interaction increases the survival and proliferation of human bone marrow-derived mesenchymal stem cells, and therefore, LIGHT might play an important role in stem cell therapy. PMID: 27835685
- We found that LTbetaR polymorphisms caused severe BPH. Thus, LTbetaR may contribute to the risk of BPH development. PMID: 26782510
- activation enhances the LPS-induced expression of IL-8 through NF-kappaB and IRF-1 PMID: 25887375
- LIGHT, via LTbetaR signaling, may contribute to exacerbation of airway neutrophilic inflammation through cytokine and chemokine production by bronchial epithelial cells. PMID: 25501580
- Relative expression of HVEM and LTbetaR modulates canonical NF-kappaB and pro-apoptotic signals stimulated by LIGHT. PMID: 24980868
- lymphotoxin-B-specific receptor. PMID: 24563505
- Dimerization of LTbetaR by LTalpha1beta2 is necessary and sufficient for signal transduction. PMID: 24248355
- Results suggest that blockade of lymphotoxin-beta receptor (LTBR) pathways may have therapeutic potential for treatment of Sjogren's syndrome. PMID: 22044682
- LTBR gene polymorphisms may be associated with risk of IgA nephropathy in Korean children PMID: 22417320
- show that a cognate interaction between LTalphabeta on CD4(+) helper T cells and LTbeta receptor on DCs results in unique signals that are necessary for optimal CD8(+) T-cell expansion via a type I IFN-dependent mechanism PMID: 21245292
- These results indicated that AdipoR1 interacted with LTBR and mediated the inhibition of LTBR-activated NF-kappaB pathway. PMID: 21195057
- LTbetaR levels are independently associated with atherosclerosis in multiple vascular beds PMID: 20599198
- Increased potential for LTbeta receptor signaling, coupled with increased bioavailability due to lower decoy receptor-3 (DcR3) avidity, provides a mechanism for polymorphic variants in LIGHT to contribute to the pathogenesis of inflammatory diseases. PMID: 20592286
- the LTbetaR modifies the ubiquitin:NIK E3 ligase, and also acts as an allosteric regulator of the ubiquitin:TRAF E3 ligase PMID: 20348096
- Modulation of cellular TRAF3 levels may thus contribute to regulation of NFkappaB-dependent gene expression by LTBR by affecting the balance of LTBR-dependent activation of canonical and non-canonical NFkappaB pathways. PMID: 20185819
- Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation.(AP-1) PMID: 12169272
- The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536. PMID: 12419817
- Data show that mRNA encoding LIGHT and its receptors [HVEM, LTbetaR, and TR6 (DcR3)] are present in placentas and cytotrophoblast cells at term. PMID: 12466117
- GA-binding protein (GABP) and Sp1 and retinoid receptors are required to mediate retinoic acid responsiveness of CD18 transcriptional activation in myeloid cells. PMID: 12485937
- ASK1 is one of the factors involved in the caspase-independent pathway of LTbetaR-induced cell death. PMID: 12566458
- TRAF2, TRAF3, cIAP1, Smac, and lymphotoxin beta receptor associate and are involved in apoptosis PMID: 12571250
- LTbetaR, CD40 and TANK interact with TRAF3 at sites that promote molecular interactions driving specific signaling PMID: 14517219
- both LTbetaR and HVEM can discriminatively mediate the expression of different genes in cultured human umbilical vein endothelial cells, including LIGHT, a proinflammatory cytokine PMID: 15917993
- Signaling through the lymphotoxin beta receptor (LTbetaR) expressed on mature hepatocytes induces massive hepatomegaly; LTbetaR and its ligands define a new pathway in supporting liver regeneration PMID: 16002734
- Blockade of TNFSF14 signaling caused a substantial reduction in the expression of lymphotoxin beta receptor (LTbetaR)-controlled migration factors within the islets and disrupts organization of tertiary structures, leading to prevention of diabetes. PMID: 16934497
- membrane-bound receptor that mediates apoptosis (LTbetaR) was present in syncytiotrophoblast and cytotrophoblast cells in all samples but were detected in placental stromal cells only at week 8 and thereafter PMID: 17010447
- Evidence in this review indicates that double positive-thymocytes regulate the differentiation of early thymocyte progenitors and gamma delta T cells through a mechanism dependent on LT beta receptor. PMID: 17336158
- These results define a model for the study of inflammatory lymphangiogenesis in the thyroid and implicate lymphotoxin beta receptor signaling in this process. PMID: 17360402
- This review discusses recent studies indicating that LT beta R signaling is required for liver regeneration, hepatitis, and hepatic lipid metabolism. PMID: 17896993
- Lymphotoxin beta receptor ligation directly activates gene expression in human vascular endothelial cells via both noncanonical and classical NF-kappa B pathways. PMID: 18292573
- LTbeta-R constitutively induces NF-kappaB activation, and this event may be associated with autonomous growth of melanoma cells. PMID: 18347013
- lymphotoxin beta receptor (LTbetaR) was detected in Rheumatoid arthritis fibroblast-like synoviocytes PMID: 18412315
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亞細(xì)胞定位：Membrane; Single-pass type I membrane protein.
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