IL13RA1 Recombinant Monoclonal Antibody
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中文名稱：IL13RA1重組抗體
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貨號：CSB-RA011591MA1HU
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規格：￥1320
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圖片：
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IHC image of CSB-RA011591MA1HU diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
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其他：
產品詳情
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產品描述：CSB-RA011591MA1HU IL13RA1重組單克隆抗體是針對人源白介素13受體α1亞基（IL13RA1）開發的高特異性科研工具。該抗體靶向IL13RA1蛋白，該分子作為IL-13信號通路的關鍵組分，廣泛參與Th2型免疫應答調控，并在過敏性疾病、組織纖維化及腫瘤免疫微環境調節中發揮重要作用。經嚴格驗證，本產品在ELISA實驗中展現出優異的抗原結合能力，同時適用于石蠟包埋組織切片的免疫組化檢測，推薦使用濃度為1:50至1:200，能清晰顯示目標蛋白在組織中的定位分布。其重組單克隆特性確保了批次間的高度一致性，適用于免疫機制研究、疾病模型構建及病理樣本分析等科研場景，為探索IL13RA1在炎癥相關疾病和腫瘤生物學中的功能提供了可靠工具。
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Uniprot No.：
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基因名：
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別名：IL13RA1 Recombinant Monoclonal Antibody
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反應種屬：Human
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免疫原：Recombinant Human IL13RA1 protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：hIgG1
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純化方式：Affinity-chromatography
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克隆號：10E7
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
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基因功能參考文獻：
- High IL13RA1 expression is associated with Invasive breast Cancer. PMID: 28634667
- in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease. PMID: 28528324
- sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism. PMID: 28874358
- IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair. PMID: 26153764
- required for induction of the alternative macrophage activation pathway by IL-13 but not by IL-4 PMID: 25766112
- Results identified FAM120A in the IL13/IL13Ralpha2 signaling pathway as a key mediator of invasion and liver metastasis in colon cancer. PMID: 25896327
- miR-143 regulation of IL-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients probably partly depends on inhibition of IL13Ralpha1. PMID: 25529447
- MiR-143 may be associated with allergic reaction in human mast cells via downregulation of IL13RA1. PMID: 23965966
- In humans, IL-13Ralpha1 lies within the PARK12 locus of susceptibility to Parkinson's disease and may have a role in the pathogenesis of this neurodegenerative disease. PMID: 23169588
- These results indicate that an inherited polymorphism of the IL-4R controls the ability of the human immune system to regulate the magnitude of IL-17 production PMID: 21294892
- The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility. PMID: 21425907
- IL-13Ralpha1 is expressed on human CD4(+) T(H)17 cells PMID: 21236478
- Mutation and functional analysis in human malignant glioma cells PMID: 11939409
- IL4RA and STAT6 are candidate genes for atopic disorders. 26 single-nucleotide polymorphisms (SNPs)and simple repeats are being reported spanning a total of 147kb in IL4RA and STAT6 genes of the Indian population PMID: 12522691
- Allele frequency of IL13RA1 polymorphism was not associated with rapid decline of lung function in smokers. PMID: 12594065
- Overexpression of IL-13Ralpha1 may play some role in pathogenesis of chronic stage of atopic dermatitis or psoriasis. PMID: 14527737
- Bronchial submucosal mast cell IL-13 receptor alpha 1 expression is higher in asthmatics than normal controls. PMID: 16918506
- IL-13Ralpha1 polymorphism was associated with higher total IgE in children with atopic asthma PMID: 17006604
- the IL13RA1 subunit gene -281T>G and 1365A>G polymorphisms do not contribute to asthma susceptibility or severity, although the IL13RA1 subunit gene locus might be involved in the control of immunoglobulin E production PMID: 17392323
- concomitant expression of IL-13Ralpha1 and IL-13Ralpha2 may be associated with the pathogenesis of idiopathic interstitial pneumonia. PMID: 19654941
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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蛋白家族：Type I cytokine receptor family, Type 5 subfamily
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組織特異性：Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
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數據庫鏈接：
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