CEACAM8 Recombinant Monoclonal Antibody
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中文名稱：CEACAM8重組抗體
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貨號(hào)：CSB-RA937940A0HU
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規(guī)格：￥1320
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圖片：
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Overlay Peak curve showing A549 cells surface stained with CSB-RA937940A0HU (red line) at 1:50. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CEACAM8重組單克隆抗體（CUSABIO貨號(hào)：CSB-RA937940A0HU）是針對(duì)粒細(xì)胞特異性標(biāo)志物CEACAM8開(kāi)發(fā)的高特異性檢測(cè)工具。CEACAM8作為癌胚抗原相關(guān)細(xì)胞黏附分子家族成員，在中性粒細(xì)胞活化、炎癥反應(yīng)及病原體防御中發(fā)揮重要作用。本產(chǎn)品經(jīng)過(guò)嚴(yán)格的ELISA和流式細(xì)胞術(shù)（FC）驗(yàn)證，能特異性識(shí)別天然構(gòu)象的CEACAM8蛋白，F(xiàn)C推薦使用稀釋比為1:50-1:200，適用于體外檢測(cè)人源樣本中CEACAM8的表達(dá)水平。在科研領(lǐng)域，該抗體可應(yīng)用于粒細(xì)胞亞群分型、炎癥相關(guān)免疫細(xì)胞功能研究，以及感染性疾病或自身免疫性疾病模型中粒細(xì)胞活化機(jī)制的探索。其重組單克隆特性保障了批次間的高度一致性，為細(xì)胞表面標(biāo)記分析、免疫應(yīng)答機(jī)制研究提供可靠工具，助力研究者深入解析CEACAM8在先天免疫調(diào)控中的生物學(xué)功能。
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Uniprot No.：
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基因名：
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別名：Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b), CEACAM8, CGM6
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反應(yīng)種屬：Human
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免疫原：A synthesized peptide derived from Human CEACAM8
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號(hào)：24H12
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, FC
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推薦稀釋比：
Application Recommended Dilution FC 1:50-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.
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基因功能參考文獻(xiàn)：
- Increased CD66b positive tumor-infiltrating neutrophils (CD66b + TINs) was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. PMID: 27863478
- Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another. PMID: 26483485
- Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls. PMID: 23686079
- The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation. PMID: 21470677
- All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes. PMID: 17909799
- CD66b molecules are involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b. PMID: 18056392
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亞細(xì)胞定位：Cell membrane; Lipid-anchor, GPI-anchor. Cell surface.
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蛋白家族：Immunoglobulin superfamily, CEA family
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組織特異性：Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
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數(shù)據(jù)庫(kù)鏈接：
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