CD96 Recombinant Monoclonal Antibody
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中文名稱：CD96重組抗體
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貨號(hào)：CSB-RA004971A0HU
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規(guī)格：￥1320
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圖片：
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The Binding Activity of CD96 with anti-CD96 antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD96(CSB-MP004971HU1(F2)) at 2 μg/mL can bind Anti-CD96 recombinant antibody, the EC50 is 95.78-127.1 ng/mL.
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CD96 Recombinant Monoclonal Antibody（Code：CSB-RA004971A0HU）是一款高特異性抗體，靶向CD96分子——一種在免疫調(diào)節(jié)中起關(guān)鍵作用的跨膜蛋白。CD96作為免疫球蛋白超家族成員，主要在T細(xì)胞、NK細(xì)胞等免疫細(xì)胞表面表達(dá)，通過(guò)與其配體CD155的相互作用參與細(xì)胞間信號(hào)傳導(dǎo)，在腫瘤免疫逃逸、自身免疫性疾病等病理過(guò)程中具有研究?jī)r(jià)值。本產(chǎn)品采用重組技術(shù)制備，具有嚴(yán)格的批次間一致性，經(jīng)ELISA實(shí)驗(yàn)驗(yàn)證可特異性識(shí)別天然及重組CD96蛋白，適用于靶蛋白的定性或半定量檢測(cè)。在科研領(lǐng)域，該抗體可應(yīng)用于免疫細(xì)胞功能研究、腫瘤微環(huán)境分析、免疫檢查點(diǎn)調(diào)控機(jī)制探索等方向，例如通過(guò)ELISA檢測(cè)細(xì)胞培養(yǎng)上清或血清樣本中的CD96表達(dá)水平，為揭示其在免疫應(yīng)答中的作用提供可靠工具。產(chǎn)品僅限科研使用，不適用于臨床診斷或其他非研究用途。
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Uniprot No.：
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基因名：
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別名：CD96; T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD antigen CD96
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反應(yīng)種屬：Human
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免疫原：Recombinant Human CD96 protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：hIgG1
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純化方式：Affinity-chromatography
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克隆號(hào)：4A4
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
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基因功能參考文獻(xiàn)：
- Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells PMID: 29531070
- Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice. PMID: 27620276
- CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes PMID: 26642704
- In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID: 24751333
- down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course. PMID: 23272144
- CD96 could serve as a target structure for effector cell-mediated lysis. PMID: 22879978
- The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression. PMID: 21729528
- CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. PMID: 15034010
- CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells PMID: 17576927
- CD96-driven adhesion to CD155 may be crucial in developmental processes PMID: 19056733
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相關(guān)疾病：C syndrome (CSYN)
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亞細(xì)胞定位：Membrane; Single-pass type I membrane protein.
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組織特異性：Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
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數(shù)據(jù)庫(kù)鏈接：
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